Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe

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	Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe
	Wang, Zuoren
刊名	NEURON
	2010
卷号	67 期号:6 页码:1021-1033
关键词	OLFACTORY INFORMATION MOLECULAR-BASIS NEURONS FLY TRANSMISSION INHIBITION MECHANISMS CRAYFISH CIRCUIT BULB
ISSN号	0896-6273
通讯作者	Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China,zuorenwang@ion.ac.cn
英文摘要	Local interneurons in the Drosophila antennal lobe are thought to play important roles in shaping odor responses. However, the physiological properties of excitatory local interneurons (eLNs) and their connectivity in the antennal lobe remain unclear. We first characterized the firing patterns of krasavietz-Gal4-labeled eLNs (krasavietz eLNs) in response to depolarizing currents. Paired recordings of krasavietz eLNs and PNs showed reciprocal excitatory connections mediated by dendrodendritic cholinergic synapses and gap junctions. Reciprocal connections were also found between two krasavietz eLNs but were rare between krasavietz eLNs and inhibitory LNs. Analysis of response onset latencies showed that krasavietz eLNs received monosynaptic inputs from ORNs. Furthermore, each eLN responded with distinct patterns to different odors, and each odor elicited distinct responses in different eLNs, with specific temporal patterns of spiking, indicating that eLNs serve specific coding functions in addition to global excitation in Drosophila olfactory processing.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	[973-2006CB806604]; [NSF30625020]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1579]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经环路与动物行为研究组
推荐引用方式 GB/T 7714	Wang, Zuoren. Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe[J]. NEURON,2010,67(6):1021-1033.
APA	Wang, Zuoren.(2010).Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe.NEURON,67(6),1021-1033.
MLA	Wang, Zuoren."Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe".NEURON 67.6(2010):1021-1033.