Effects of low level of methylmercury on proliferation of cortical progenitor cells

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	Effects of low level of methylmercury on proliferation of cortical progenitor cells
	Xu, Mingyu ; Yan, Chonghuai ; Tian, Ying ; Yuan, Xiaobing ; Shen, Xiaoming
刊名	BRAIN RESEARCH
	2010
卷号	1359 期号:pt 1 页码:272-280
关键词	Methylmercury Neural progenitor cells Proliferation Cyclin E NEURAL STEM-CELLS DEVELOPMENTAL EXPOSURE CYCLE PROGRESSION MERCURY EXPOSURE DEVELOPING BRAIN RAT-BRAIN G1 PHASE NEUROGENESIS TOXICITY DIFFERENTIATION
ISSN号	0006-8993
通讯作者	Shen, XM (reprint author), Shanghai Jiao Tong Univ, XinHua Hosp, Sch Med,Shanghai Inst Pediat Res, Shanghai Key Lab Childrens Environm Hlth, Shanghai 200092, Peoples R China,xmshen@shsmu.edu.cn
英文摘要	Methylmercury (MeHg) is a potent environmental neurotoxin that shows toxicity to developing central nervous system (CNS), causing brain damage in children even at low exposure levels. However, the mechanisms for its effect on CNS are not well understood. In current study, primary cultures of progenitor cells from embryonic cerebral cortex were used as a model system to study the potential effect and the underlying mechanism of MeHg on neural progenitor cells. Results showed that, in cultured cortical progenitor cells, 48-h exposure to low-level of MeHg (at 2.5 nM, 5 nM and 50 nM, respectively) caused G1/S cell cycle arrest in a dose-dependent manner without inducing cell death. Interestingly, the expression of cyclin E, which promotes G1/S transition, but not cyclin D1 and CDK2, was selectively downregulated by exposure of MeHg. In addition, low-level of MeHg inhibited the maintenance of ERK1/2 phosphorylation, possibly by abolishing the late phase ERK1/2 activation induced by bFGF. Thus, MeHg may induce proliferation inhibition and cell cycle arrest of neural progenitor cells via regulating cyclin E expression and perturbing a pathway that involves ERK1/2. (C) 2010 Elsevier B.V. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30872806]; Foundation for Open Projects of Key Laboratory of Neuroscience, Chinese Academy of Sciences[SKLN-2008B04]; Shanghai Key Laboratory of Children
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1566]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Xu, Mingyu,Yan, Chonghuai,Tian, Ying,et al. Effects of low level of methylmercury on proliferation of cortical progenitor cells[J]. BRAIN RESEARCH,2010,1359(pt 1):272-280.
APA	Xu, Mingyu,Yan, Chonghuai,Tian, Ying,Yuan, Xiaobing,&Shen, Xiaoming.(2010).Effects of low level of methylmercury on proliferation of cortical progenitor cells.BRAIN RESEARCH,1359(pt 1),272-280.
MLA	Xu, Mingyu,et al."Effects of low level of methylmercury on proliferation of cortical progenitor cells".BRAIN RESEARCH 1359.pt 1(2010):272-280.