Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice

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	Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice
	Liu, Yan ; Jiang, Yun'ai ; Si, Yunxia ; Kim, Ji-Young ; Chen, Zhou-Feng ; Rao, Yi
刊名	NATURE
	2011
卷号	472 期号:7341 页码:95-U125
关键词	PARA CHLOROPHENYLALANINE COPULATORY BEHAVIOUR MALE RATS SEROTONIN LACKING INNATE TRP2 MEN
ISSN号	0028-0836
通讯作者	Rao, Y (reprint author), Natl Inst Biol Sci, Beijing 102206, Peoples R China,yrao@pku.edu.cn
英文摘要	Although the question of to whom a male directs his mating attempts(1,2) is a critical one in social interactions, little is known about the molecular and cellular mechanisms controlling mammalian sexual preference. Here we report that the neurotransmitter 5-hydroxytryptamine (5-HT) is required for male sexual preference. Wild-type male mice preferred females over males, but males lacking central serotonergic neurons lost sexual preference although they were not generally defective in olfaction or in pheromone sensing. A role for 5-HT was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (Tph2), which is required for the first step of 5-HT synthesis in the brain. Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wildtype level, adult Tph2 knockout mice also preferred females over males. These results indicate that 5-HT and serotonergic neurons in the adult brain regulate mammalian sexual preference.
学科主题	Science & Technology - Other Topics
收录类别	SCI
资助信息	Ministry of Science and Technology[2010CB833901]; Beijing Municipal Commission on Science and Technology; NIH
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1544]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liu, Yan,Jiang, Yun'ai,Si, Yunxia,et al. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice[J]. NATURE,2011,472(7341):95-U125.
APA	Liu, Yan,Jiang, Yun'ai,Si, Yunxia,Kim, Ji-Young,Chen, Zhou-Feng,&Rao, Yi.(2011).Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.NATURE,472(7341),95-U125.
MLA	Liu, Yan,et al."Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice".NATURE 472.7341(2011):95-U125.