Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila

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	Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila
	Liu, Weiwei ; Liang, Xinhua ; Gong, Jianxian ; Yang, Zhen ; Zhang, Yao-Hua ; Zhang, Jian-Xu ; Rao, Yi
刊名	NATURE NEUROSCIENCE
	2011
卷号	14 期号:7 页码:896-U119
关键词	ANTENNAL LOBE CAENORHABDITIS-ELEGANS MELANOGASTER BEHAVIOR EXPERIENCE CIRCUIT SYSTEM REPRESENTATION STIMULATION ADAPTATION
ISSN号	1097-6256
通讯作者	Rao, Y (reprint author), Natl Inst Biol Sci, Beijing, Peoples R China,yrao@pku.edu.cn
英文摘要	When two socially naive Drosophila males meet, they will fight. However, prior social grouping of males reduces their aggression. We found olfactory communication to be important for modulating Drosophila aggression. Although acute exposure to the male-specific pheromone 11-cis-vaccenyl acetate (cVA) elicited aggression through Or67d olfactory receptor neurons (ORNs), chronic cVA exposure reduced aggression through Or65a ORNs. Or65a ORNs were not acutely involved in aggression, but blockade of synaptic transmission of Or65a ORNs during social grouping or prior chronic cVA exposure eliminated social modulation of aggression. Artificial activation of Or65a ORNs by ectopic expression of the Drosophila gene TrpA1 was sufficient to reduce aggression. Social suppression of aggression requires subsets of local interneurons in the antennal lobe. Our results indicate that activation of Or65a ORNs is important for social modulation of male aggression, demonstrate that the acute and chronic effects of a single pheromone are mediated by two distinct types of ORNs, reveal a behaviorally important role for interneurons and suggest a chemical method to reduce aggression in animals.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	Ministry of Science and Technology[2010CB833900]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1535]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liu, Weiwei,Liang, Xinhua,Gong, Jianxian,et al. Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila[J]. NATURE NEUROSCIENCE,2011,14(7):896-U119.
APA	Liu, Weiwei.,Liang, Xinhua.,Gong, Jianxian.,Yang, Zhen.,Zhang, Yao-Hua.,...&Rao, Yi.(2011).Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila.NATURE NEUROSCIENCE,14(7),896-U119.
MLA	Liu, Weiwei,et al."Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila".NATURE NEUROSCIENCE 14.7(2011):896-U119.