Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli

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	Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli
	Poo, Mu-ming
刊名	JOURNAL OF NEUROSCIENCE
	2009
卷号	29 期号:18 页码:6013-6021
关键词	LESS-THAN-1 HZ OSCILLATION NETWORK MECHANISMS PURKINJE-CELLS SPINY NEURONS IN-VIVO CORTEX SLEEP FLUCTUATIONS BISTABILITY VARIABILITY
ISSN号	0270-6474
通讯作者	He, JF (reprint author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China,Jufang.He@inet.polyu.edu.hk ; xhzhang@ion.ac.cn
英文摘要	Slow oscillations at frequencies <1 Hz manifest in many brain regions as discrete transitions between a depolarized up state and a hyperpolarized down state of the neuronal membrane potential. Although up and down states are known to differentially affect sensory-evoked responses, whether and how they are modulated by sensory stimuli are not well understood. In the present study, intracellular recording in anesthetized guinea pigs showed that membrane potentials of nonlemniscal auditory thalamic neurons exhibited spontaneous up/down transitions at random intervals in the range of 2-30 s, which could be entrained to a regular interval by repetitive sound stimuli. After termination of the entraining stimulation (ES), regular up/down transitions persisted for several cycles at the ES interval. Furthermore, the efficacy of weak sound stimuli in triggering the up-to-down transition was potentiated specifically at the ES interval for at least 10 min. Extracellular recordings in the auditory thalamus of unanesthetized guinea pigs also showed entrainment of slow oscillations by rhythmic sound stimuli during slow wave sleep. These results demonstrate a novel form of network plasticity, which could help to retain the information of stimulus interval on the order of seconds.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	Chinese Academy of Sciences[KSCX2-YW-R-29]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1659]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组
推荐引用方式 GB/T 7714	Poo, Mu-ming. Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli[J]. JOURNAL OF NEUROSCIENCE,2009,29(18):6013-6021.
APA	Poo, Mu-ming.(2009).Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli.JOURNAL OF NEUROSCIENCE,29(18),6013-6021.
MLA	Poo, Mu-ming."Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli".JOURNAL OF NEUROSCIENCE 29.18(2009):6013-6021.