Long-range retrograde spread of LTP and LTD from optic tectum to retina

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	Long-range retrograde spread of LTP and LTD from optic tectum to retina
	Poo, Mu-ming
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2009
卷号	106 期号:45 页码:18890-18896
关键词	neural development retrograde signaling synaptic plasticity retinal ganglion cell PRESYNAPTIC NEURONAL EXCITABILITY DEVELOPING RETINOTECTAL SYSTEM REMODELING IN-VIVO TERM POTENTIATION NEUROTROPHIC FACTOR SYNAPTIC PLASTICITY LASTING POTENTIATION MAMMALIAN BRAIN NEURAL-NETWORKS VISUAL-SYSTEM
ISSN号	0027-8424
通讯作者	Poo, MM (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA,mpoo@berkeley.edu
英文摘要	Neural activity can induce persistent strengthening or weakening of synapses, known as long-term potentiation (LTP) or long-term depression (LTD), respectively. As potential cellular mechanisms underlying learning and memory, LTP and LTD are generally regarded as synapse-specific "imprints'' of activity, although there is evidence in vitro that LTP/LTD may spread to adjacent synapses. Here, we report that LTP and LTD induced in vivo at retinotectal synapses of Xenopus tadpoles undergo rapid long-range retrograde spread from the optic tectum to the retina, resulting in potentiation and depression of bipolar cell synapses on the dendrites of retinal ganglion cells, respectively. The retrograde spread of LTP and LTD required retrograde signaling initiated by brain-derived neurotrophic factor and nitric oxide in the tectum, respectively. Such bidirectional adjustment of the strength of input synapses in accordance to that of output synapses may serve to coordinate developmental refinement and learning functions of neural circuits.
学科主题	Science & Technology - Other Topics
收录类别	SCI
资助信息	National Institutes of Health[EY01979, NS36999]; National Basic Research of China[2006CB806605, 2006CB943802]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1630]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组
推荐引用方式 GB/T 7714	Poo, Mu-ming. Long-range retrograde spread of LTP and LTD from optic tectum to retina[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(45):18890-18896.
APA	Poo, Mu-ming.(2009).Long-range retrograde spread of LTP and LTD from optic tectum to retina.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(45),18890-18896.
MLA	Poo, Mu-ming."Long-range retrograde spread of LTP and LTD from optic tectum to retina".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.45(2009):18890-18896.