Functional roles of TRPC channels in the developing brain

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	Functional roles of TRPC channels in the developing brain
	Wang, Yizheng
刊名	PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
	2009
卷号	458 期号:2 页码:283-289
关键词	Neurone INOSITOL 1 Brain 4 Development 5-TRISPHOSPHATE RECEPTORS TRP channels Synaptic mechanisms CEREBELLAR GRANULE NEURONS NERVE GROWTH CONES NEUROTROPHIC FACTOR CA2+ ENTRY CALCIUM TRANSIENTS CELL-PROLIFERATION DENDRITIC GROWTH ACTIVATION PROTEIN
ISSN号	0031-6768
通讯作者	Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, Lab Neural Signal Transduct, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
英文摘要	Transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane domains. These channels can be activated through a phospholipase-C-dependent mechanism, making them sensors for environmental cues. Their expression begins early in embryonic days and remains in adulthood. These channels have important roles in the processes of neuronal development, including neural stem cell proliferation, cerebellar granule cell survival, axon path finding, neuronal morphogenesis, and synaptogenesis. In this review, we will discuss functional implications of TRPC channels during brain development.
学科主题	Physiology
收录类别	SCI
资助信息	National Natural Science Foundation of China[2006CB806600, 30711120566, 30621062]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1658]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组
推荐引用方式 GB/T 7714	Wang, Yizheng. Functional roles of TRPC channels in the developing brain[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,2009,458(2):283-289.
APA	Wang, Yizheng.(2009).Functional roles of TRPC channels in the developing brain.PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,458(2),283-289.
MLA	Wang, Yizheng."Functional roles of TRPC channels in the developing brain".PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 458.2(2009):283-289.