Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain

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	Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
	Zhang, X; Zhang, X
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2002
卷号	99 期号:12 页码:8360-8365
关键词	NERVE INJURY SENSORY NEURONS NEUROTROPHIC FACTOR SODIUM-CHANNELS BENZODIAZEPINE RECEPTOR CALCIUM-CHANNEL NEUROPEPTIDE-Y SCIATIC-NERVE UP-REGULATION CA2+ CHANNEL
ISSN号	0027-8424
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
英文摘要	Phenotypic modification of dorsal root ganglion (DRG) neurons represents an important mechanism underlying neuropathic pain. However, the nerve injury-induced molecular changes are not fully identified. To determine the molecular alterations in a broader way, we have carried out cDNA array on the genes mainly made from the cDNA libraries of lumbar DRGs of normal rats and of rats 14 days after peripheral axotomy. Of the 7,523 examined genes and expressed sequence tags (ESTs), the expression of 122 genes and 51 expressed sequence tags is strongly changed. These genes encompass a large number of members of distinct families, including neuropeptides, receptors, ion channels, signal transduction molecules, synaptic vesicle proteins, and others. Of particular interest is the up-regulation of gamma-aminobutyric acidA receptor alpha5 subunit, peripheral benzodiazepine receptor, nicotinic acetylcholine receptor alpha7 subunit, P2Y1 purinoceptor, Na+ channel beta2 subunit, and L-type Ca2+ channel alpha2delta-1 subunit. Our findings therefore reveal dynamic and complex changes in molecular diversity among DRG neurons after axotomy.
学科主题	Science & Technology - Other Topics
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2054]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组
推荐引用方式 GB/T 7714	Zhang, X,Zhang, X. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2002,99(12):8360-8365.
APA	Zhang, X,&Zhang, X.(2002).Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,99(12),8360-8365.
MLA	Zhang, X,et al."Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99.12(2002):8360-8365.