NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies

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	NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies
	Guo, A.
刊名	GENES BRAIN AND BEHAVIOR
	2010
卷号	9 期号:3 页码:325-334
关键词	Critical period Drosophila experience-dependent plasticity NMDAR1 phototaxis preference behavior visual deprivation OCULAR DOMINANCE PLASTICITY DROSOPHILA-MELANOGASTER MOLECULAR-BASIS EXPERIENCE CORTEX SYSTEM MEMORY EXPRESSION JUVENILE MICE
ISSN号	1601-1848
通讯作者	Guo, A (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China,akguo@ion.ac.cn
英文摘要	Adult mammals have experience-dependent plasticity in visual system, but it is unclear whether adult insects also have this plasticity after the critical period of visual development. Here, we have established a modified Y-maze apparatus for investigating experience-dependent plasticity in Drosophila. Using this setup we demonstrate that flies after the critical period have bidirectional modifications of the phototaxis preference behavior (PPB) induced by visual deprivation and experience: Visual deprivation decreases the preference of flies for visible light, while visual experience exerts the opposite effect. We also found an age-dependent PPB plasticity induced by visual deprivation. Molecular and cellular studies suggest that the N-methyl- d-aspartate receptors (NMDARs) mediate ocular dominance plasticity in visual cortex in mammals, but direct behavioral evidence is lacking. Here, we used the genetic approaches to demonstrate that NMDAR1, which is NMDARs subunit in Drosophila, can mediate PPB plasticity in young and adult flies. These findings provide direct behavioral evidence that NMDAR1 mediates PPB plasticity in Drosophila. Our results suggest that mammals and insects have analogous mechanisms for experience-dependent plasticity and its regulation by NMDAR signaling.
学科主题	Behavioral Sciences ; Neurosciences & Neurology
收录类别	SCI
资助信息	NSFC[30270341, 30630028, 30621004, 30770511]; National Basic Research Program of China[G2000077800, 2006CB806600, 2006CB911003]; CAS[KJCX1-09-03, KSCX2-YWR-28]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1601]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_学习与记忆研究组
推荐引用方式 GB/T 7714	Guo, A.. NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies[J]. GENES BRAIN AND BEHAVIOR,2010,9(3):325-334.
APA	Guo, A..(2010).NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies.GENES BRAIN AND BEHAVIOR,9(3),325-334.
MLA	Guo, A.."NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies".GENES BRAIN AND BEHAVIOR 9.3(2010):325-334.