Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells
	Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai
刊名	FOOD AND AGRICULTURAL IMMUNOLOGY
	2009
卷号	20 期号:1 页码:67-77
关键词	anti-inflammatory activity endophytic Streptomyces lansai C RAW 264 7 cells NITRIC-OXIDE PRODUCTION MACROPHAGES LIPOPOLYSACCHARIDE CYCLOOXYGENASE-2 INFLAMMATION CYTOKINES PAIN
ISSN号	0954-0105
通讯作者	Taechowisan, T (reprint author), Silpakorn Univ, Dept Microbiol, Nakhon Pathom 73000, Thailand. tthongch@su.ac.th
英文摘要	This research was undertaken to find the in vitro inflammatory action of lansai A-D produced by Streptomyces sp. SUC1. We investigated the effects of lansai C not only on the formation of nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor (TNF-), interleukin (IL)-1, IL-6 and IL-10, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of inducible nitric oxide synthase enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, lansai C also mildly but significantly reduced the formation of TNF-. These findings support the application of lansai C as anti-inflammatory agent.
学科主题	Chemistry, Applied; Food Science & Technology; Immunology; Toxicology
收录类别	SCI
资助信息	Thailand Research Fund[MRG5180173]
语种	英语
公开日期	2012-10-12
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/15378]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,et al. Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2009,20(1):67-77.
APA	Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,&Liu, Jikai.(2009).Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells.FOOD AND AGRICULTURAL IMMUNOLOGY,20(1),67-77.
MLA	Taechowisan, Thongchai,et al."Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells".FOOD AND AGRICULTURAL IMMUNOLOGY 20.1(2009):67-77.