Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海原子核所2003年前

	Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies
	Li, QN（李晴暖） ; Xiu, Y ; Zhang, XD（张晓冬） ; Liu, RL（刘瑞丽） ; Du, QQ ; Shun, XG ; Chen, SL ; Li, WX（李文新）
刊名	NUCLEAR MEDICINE AND BIOLOGY
	2002
卷号	29 期号:6 页码:707
ISSN号	0969-8051
英文摘要	The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C-60 derivative for biodistriburtion studies, the Tc-99m-labeling of C-60(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the Tc-99m-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that Tc-99m-C-60(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h. (C) 2002 Elsevier Science Inc. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000177372100012
公开日期	2012-09-25
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/10121]
专题	上海应用物理研究所_中科院上海原子核所2003年前
推荐引用方式 GB/T 7714	Li, QN,Xiu, Y,Zhang, XD,et al. Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies[J]. NUCLEAR MEDICINE AND BIOLOGY,2002,29(6):707.
APA	Li, QN.,Xiu, Y.,Zhang, XD.,Liu, RL.,Du, QQ.,...&Li, WX.(2002).Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies.NUCLEAR MEDICINE AND BIOLOGY,29(6),707.
MLA	Li, QN,et al."Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies".NUCLEAR MEDICINE AND BIOLOGY 29.6(2002):707.