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Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site
Wenlong Li; Honghao Sun; Feijie Xu; Wen Shuai; Jie Liu; Shengtao Xu; Hequan Yao; Cong Ma; Zheying Zhu; Jinyi Xu
刊名Bioorganic Chemistry
2019
卷号Vol.85页码:49-59
关键词Tubulin inhibitor Vinyl sulfone Indole Colchicine site Drug-likeness
ISSN号0045-2068
URL标识查看原文
公开日期[db:dc_date_available]
内容类型期刊论文
URI标识http://www.corc.org.cn/handle/1471x/4606536
专题湖南大学
作者单位1.b State Key Laboratory of Chemical Biology and Drug Discovery, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong
2.Division of Molecular Therapeutics & Formulation, School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham N
3.2RD, UK a State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China
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GB/T 7714
Wenlong Li,Honghao Sun,Feijie Xu,et al. Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site[J]. Bioorganic Chemistry,2019,Vol.85:49-59.
APA Wenlong Li.,Honghao Sun.,Feijie Xu.,Wen Shuai.,Jie Liu.,...&Jinyi Xu.(2019).Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.Bioorganic Chemistry,Vol.85,49-59.
MLA Wenlong Li,et al."Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site".Bioorganic Chemistry Vol.85(2019):49-59.
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