The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4

	The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4
	Dang, Yibing 1; Li, Sheng 1; Wang, Wenxia 2; Wang, Shujing 1; Zou, Mingming 1; Guo, Yanjie 1; Fan, Jianhui 1; Du, Yuguang 2; Zhang, Jianing 1
刊名	carbohydrate polymers
	2011-01-30
卷号	83 期号:3 页码:1075-1081
关键词	Chitosan oligosaccharide Spleen dendritic cell TLR4 Immune response
ISSN号	0144-8617
通讯作者	杜昱光 ; zhangjn
产权排序	2,3
中文摘要	the effects of chitosan oligosaccharide on the activation of murine spleen cd11c(+) dendritic cells via toll-like receptor 4
英文摘要	to investigate the effects of chitosan oligosaccharide (cos) on dendritic cells (dcs) and the role of toll-like receptor 4 (tlr4) in this immune process, murine spleen cd11c(+) dendritic cells (sdcs) were isolated and cultured with s-cos and b-cos with polymeration degree of 3-7 and 7-16, respectively. the results showed that 8-cos up-regulated the expressions of mhcii and cd86 on sdcs, promoted the secretion of tnf-alpha from sdcs. sdcs treated with b-cos stimulated the proliferation of the cd4(+)t cells. however, these effects were not observed on sdcs treated with s-cos. importantly, silencing the tlr4 expressions on sdcs by rna interference approach attenuated the expression of cd86, mhcii on sdcs, and the secretion of tnf-alpha from sdcs, and the stimulating cd4(+)t cells proliferation capacity of sdcs induced by b-cos. these results suggest that b-cos, but not s-cos, promotes the activation of sdcs and tlr4 plays a bridge role in this process. (c) 2010 elsevier ltd. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, applied ; chemistry, organic ; polymer science
研究领域[WOS]	chemistry ; polymer science
关键词[WOS]	rna interference ; ifn-gamma ; in-vivo ; delivery ; subsets ; mice ; oligochitosan ; maturation ; inhibit
收录类别	SCI
语种	英语
WOS记录号	WOS:000286965300005
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115522]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Dept Biochem, Inst Glycobiol, Dalian 116044, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116001, Peoples R China
推荐引用方式 GB/T 7714	Dang, Yibing,Li, Sheng,Wang, Wenxia,et al. The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4[J]. carbohydrate polymers,2011,83(3):1075-1081.
APA	Dang, Yibing.,Li, Sheng.,Wang, Wenxia.,Wang, Shujing.,Zou, Mingming.,...&Zhang, Jianing.(2011).The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4.carbohydrate polymers,83(3),1075-1081.
MLA	Dang, Yibing,et al."The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4".carbohydrate polymers 83.3(2011):1075-1081.