Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin

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	Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin
	Zhang, Peng（张鹏） ; Li, Haixia（李海霞） ; Liu, Yancheng ; Yao, Side（姚思德） ; Wang, Wenfeng（王文锋）
刊名	ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
	2011
卷号	225 期号:8 页码:843
ISSN号	0942-9352
英文摘要	The photochemical properties of 4'-N-acetyl derivative of norfloxacin (ANFX) were investigated in different solutions. Both UV-Vis absorption and the quantum yields of excited states are pH-dependent, and pK(a) value of ground state for the protonation of 3-carboxylic group was determined to be 6.5 +/- 0.2. Pulse radiolysis and laser flash photolysis experiments were carried out to characterize transient species of ANFX and to investigate reactions with tryptophan (TrpH) and 2'-seoxyguanosine-5'-monophosphoric acid disodium salt (dGMP). The ANFX undergoes the photoejection of electron by a mixed mechanism of one-photon and two-photon processes. Under moderate laser energy conditions, two-photon process is predominantly. The ANFX radical dianion (ANFX(-H)(center dot 2-)) formed in reaction with e(aq)(-) is characterized by the absorption around 370 nm, and the rate constant was determined to be 1.2 x 10(10) dm(3) mol(-1) s(-1). The (3)ANFX(-H)(-*) is able to oxidize TrpH and dGMP with bimolecular rate constants of 5.4 x 10(8) and 9.5 x 10(6) dm(3) mol(-1) s(-1), respectively. The ANFX(-H)(center dot 2-) and the oxidized radicals of TrpH and dGMP were observed directly. Under aerobic conditions, the photo-oxidations involve both type 1 and type 11 mechanisms.
收录类别	SCI
语种	英语
WOS记录号	WOS:000294693000003
公开日期	2012-07-04
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/9563]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Zhang, Peng,Li, Haixia,Liu, Yancheng,et al. Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin[J]. ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS,2011,225(8):843.
APA	Zhang, Peng,Li, Haixia,Liu, Yancheng,Yao, Side,&Wang, Wenfeng.(2011).Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin.ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS,225(8),843.
MLA	Zhang, Peng,et al."Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin".ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS 225.8(2011):843.