Preparation of luminescent and mesoporous Eu(3+)/Tb(3+) doped calcium silicate microspheres as drug carriers via a template route

	Preparation of luminescent and mesoporous Eu(3+)/Tb(3+) doped calcium silicate microspheres as drug carriers via a template route
	Kang XJ ; Huang SS ; Yang PP ; Ma PA ; Yang DM ; Lin J
刊名	dalton transactions
	2011
卷号	40 期号:9 页码:1873-1879
关键词	SIMULATED BODY-FLUID BIOACTIVE GLASSES DELIVERY SYSTEM SURFACE SBA-15 HYDROXYAPATITE WOLLASTONITE RELEASE FUNCTIONALIZATION COMPLEXES
ISSN号	1477-9226
通讯作者	ma pa
中文摘要	luminescent and mesoporous eu(3+)/tb(3+) doped calcium silicate microspheres (lmcs) were synthesized by using mesoporous silica spheres as the templates. the lmcs and drug-loaded samples were characterized by means of x-ray diffraction (xrd), field emission scanning electron microscopy (fe-sem), transmission electron microscopy (tem), fourier transform infrared spectroscopy (ft-ir), n(2) adsorption/desorption, and photoluminescence (pl) spectra. the results reveal that the lmcs have uniform spherical morphology with a diameter around 400 nm and the mesopore size of 6 nm. the prepared samples exhibit little cytotoxicity at concentrations below 5 mg ml(-1) via mtt assay. in addition, drug storage/release properties of the lmcs were demonstrated for ibuprofen (ibu). the obtained lmcs can be used to encapsulate drugs and release them. under excitation by uv light, the ibu-loaded samples still show the characteristic (5)d(0)-(7)f(1-3) emission lines of eu(3+) and the characteristic (5)d(4)-(7)f(3-6) emission lines of tb(3+). the pl intensity of eu(3+) in the drug carrier system increases with the cumulative released amount of ibu, making the drug release able to be tracked or monitored by the change of luminescence of eu(3+). the lmcs reported here with mesoporous structure, good biocompatibility and luminescent property can be a promising drug delivery carrier.
收录类别	SCI收录期刊论文
语种	英语
公开日期	2012-06-12
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/45063]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kang XJ,Huang SS,Yang PP,et al. Preparation of luminescent and mesoporous Eu(3+)/Tb(3+) doped calcium silicate microspheres as drug carriers via a template route[J]. dalton transactions,2011,40(9):1873-1879.
APA	Kang XJ,Huang SS,Yang PP,Ma PA,Yang DM,&Lin J.(2011).Preparation of luminescent and mesoporous Eu(3+)/Tb(3+) doped calcium silicate microspheres as drug carriers via a template route.dalton transactions,40(9),1873-1879.
MLA	Kang XJ,et al."Preparation of luminescent and mesoporous Eu(3+)/Tb(3+) doped calcium silicate microspheres as drug carriers via a template route".dalton transactions 40.9(2011):1873-1879.