An experimental study on imaging Burkitt's lymphoma cells by atomic force microscope

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	An experimental study on imaging Burkitt's lymphoma cells by atomic force microscope
	Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Li GY(李广勇); Xiao XB(肖秀斌); Yuan, Shunzong; Zhang WJ(张伟京)
	2010
会议名称	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
会议日期	January 20-23, 2010
会议地点	Xiamen, China
关键词	Cell membranes Liquids Microscopes Morphology Oncology Surface structure
页码	262-266
中文摘要	Burkitt's lymphoma (BL) is a highly aggressive malignant tumor with high morbidity rate in children. Patients have different responses to the same therapy due to the molecular heterogeneity. Detailed observation of the surface structure of BL cells to locate the specific receptors (CD20) on the cell surface and measure the binding force between the CD20s and their cognate ligands (Rituximab) may give people a further understanding to BL cell's intrinsic properties and provide complementary approaches for the next generation of drug research and development. In this paper, we give an experimental study on how to obtain the morphology images of the BL cells both in air and liquid with atomic force microscope (AFM).The detailed procedures such as sample preparation of BL cells, parameter setting of AFM and so on, are presented, and the experimental results illustrate that the morphology image of the BL cell can be obtained in air or liquid respectively by using AFM. ©2010 IEEE.
收录类别	EI
产权排序	1
会议录	2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
会议录出版者	IEEE Computer Society
会议录出版地	Piscataway, NJ
语种	英语
ISBN号	978-1-4244-6543-9
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/8566]
专题	沈阳自动化研究所_机器人学研究室
推荐引用方式 GB/T 7714	Li M,Liu LQ,Xi N,et al. An experimental study on imaging Burkitt's lymphoma cells by atomic force microscope[C]. 见:5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010. Xiamen, China. January 20-23, 2010.