SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae

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	SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae
	Guo, Zhenhua2 ; Adomas, Aleksandra B.1; Jackson, Erin D.3; Qin, Hong 3; Townsend, Jeffrey P.1
刊名	FEMS YEAST RESEARCH
	2011-06-01
卷号	11 期号:4 页码:345-355
关键词	transcriptomics longevity gene expression microarray life span variation
英文摘要	We investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into metabolism, transport, development, transcription or cell cycle, and organelle organization (mitochondrial, chromosomal, and cytoskeletal). With several independent validating experiments, we detected 15 genes with consistent differential expression levels between the long- and the short-lived progeny. Among those 15, SIR2, HSP30, and TIM17 were upregulated in long-lived strains, which is consistent with the known effects of gene silencing, stress response, and mitochondrial function on aging. The link between SIR2 and yeast natural life span variation offers some intriguing ties to the allelic association of the human homolog SIRT1 to visceral obesity and metabolic response to lifestyle intervention.
学科主题	Biotechnology & Applied Microbiology; Microbiology; Mycology
类目[WOS]	Biotechnology & Applied Microbiology ; Microbiology ; Mycology
研究领域[WOS]	Biotechnology & Applied Microbiology ; Microbiology ; Mycology
关键词[WOS]	LIFE-SPAN EXTENSION ; GRANGER CAUSALITY ; CALORIE RESTRICTION ; MODEL ORGANISMS ; DNA-DAMAGE ; C-ELEGANS ; LONGEVITY ; MITOCHONDRIA ; SENESCENCE ; GENOME
收录类别	SCI
语种	英语
WOS记录号	WOS:000290408800004
公开日期	2012-06-12
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/11219]
专题	昆明植物研究所_中国西南野生生物种质资源库
作者单位	1.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA 2.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Beijing 100864, Peoples R China 3.Spelman Coll, Dept Biol, Atlanta, GA 30314 USA
推荐引用方式 GB/T 7714	Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,et al. SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae[J]. FEMS YEAST RESEARCH,2011,11(4):345-355.
APA	Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,Qin, Hong,&Townsend, Jeffrey P..(2011).SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.FEMS YEAST RESEARCH,11(4),345-355.
MLA	Guo, Zhenhua,et al."SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae".FEMS YEAST RESEARCH 11.4(2011):345-355.