Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS

	Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS
	Han TJ ; Song FR ; Liu ZY ; Pi ZF ; Liu ZQ ; Liu SY
刊名	acta chimica sinica
	2011
卷号	69 期号:15 页码:1795-1802
关键词	TANDEM-MASS-SPECTROMETRY RADIX-ACONITI PERMEABILITY
ISSN号	0567-7351
通讯作者	han tj
中文摘要	a uplc/ms method has been established to analyze the diterpenoid alkaloids transportation in the aconitum carmichaeli with the caco-2 cell monolayer. different combination herbs' water extracts including radix glycyrrhizae, rhizoma zingiberis, rhizoma pinelliae or bulbus frltillariae thunbergii have been mixed with the same concentration of the aconitum carmichaeli alkaloids extract solution. the mixing ratio was converted into their medicinal herbs mass of 1 to 1. the results demonstrated that the bioavailability of the diterpenoid alkaloids especially the diester-diterpenoid alkaloids has been decreased by the adding of the radix glycyrrhizae, rhizoma zingiberis or rhizoma pinelliae extracts, which are the most toxicity compounds in the aconitum carmichaeli. however, the bioavailability of the diterpenoid alkaloids in the absorption and efflux has been increased by the adding of the bulbus frltillariae thunbergii extract, respectively.
收录类别	SCI收录期刊论文
语种	中文
WOS记录号	WOS:000294375200011
公开日期	2012-06-08
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44408]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Han TJ,Song FR,Liu ZY,et al. Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS[J]. acta chimica sinica,2011,69(15):1795-1802.
APA	Han TJ,Song FR,Liu ZY,Pi ZF,Liu ZQ,&Liu SY.(2011).Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS.acta chimica sinica,69(15),1795-1802.
MLA	Han TJ,et al."Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS".acta chimica sinica 69.15(2011):1795-1802.