Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation

	Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation
	Hu XL ; Liu S ; Huang YB ; Chen XS ; Jing XB
刊名	biomacromolecules
	2010
卷号	11 期号:8 页码:2094-2102
关键词	POLYMERIC MICELLES TARGETED DELIVERY DRUG CARRIERS SOLID TUMORS CELL-LINE NANOPARTICLES SYSTEM BLOOD
ISSN号	1525-7797
通讯作者	jing xb
中文摘要	doxorubicin (dox) was conjugated onto a biodegradable block copolymer methoxy-poly(ethylene glycol)-block-poly(lactide-co-2,2-dihydroxymethylpropylene carbonate (mpeg-b-p(la-co-dhp)) via a carbamate linkage and an acid-labile hydrazone linkage, respectively. mutifunctional mixed micelles consisting of dox-containing copolymer mpeg-b-p(la-co-dhp/dox) and folic acid-containing copolymer mpeg-b-p(la-co-dhp/fa) were successfully prepared by coassembling the two component copolymers. the mixed micelles had well-defined core shell structure and their diameters were in the range of 70-100 nm. both dox-conjugates (via carbamate or hydrazone linkage) showed ph-dependent release behavior, and the micelles with hydrazone linkage showed more ph-sensitivity compared to those with carbamate linkage. the in vitro cell uptake experiment by clsm and flow cytometry showed preferential internalization of fa-containing micelles by human ovarian cancer cell line skov-3 than that without fa. flow cytometric analysis was conducted to reveal the enhanced cell apoptosis caused by the fa-containing micelles. these results suggested that these micelles containing both chemotherapeutic and targeting ligand could be a promising nanocarrier for targeting the drugs to cancer cells and releasing the drug molecules inside the cancer cells.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000280583400026
公开日期	2012-04-26
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43559]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Hu XL,Liu S,Huang YB,et al. Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation[J]. biomacromolecules,2010,11(8):2094-2102.
APA	Hu XL,Liu S,Huang YB,Chen XS,&Jing XB.(2010).Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation.biomacromolecules,11(8),2094-2102.
MLA	Hu XL,et al."Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation".biomacromolecules 11.8(2010):2094-2102.