Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2004-2010年

	Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier
	Sun, HW（孙汉文） ; Zhang, LY ; Zhu, XJ ; Kong, CY ; Zhang, CL ; Yao, S(姚思德）
刊名	SCIENCE IN CHINA SERIES B-CHEMISTRY
	2009
卷号	52 期号:1 页码:69
ISSN号	1006-9291
通讯作者	Sun, HW (reprint author), Dezhou Univ, Dept Chem, Dezhou 253023, Peoples R China
英文摘要	One-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this paper. Poly(PEGMA) modified superparamagnetic nanogels (poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate (PEGMA) as the monomer and N, N'-methylene-bis-(acrylamide) (MBA) as the cross-linking agent in magnetite aqueous suspension under UV irradiation. The surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy (FTIR) and a thermogravimetric analyzer (TGA). The results indicated that the poly(PEGMA) magnetic nanogels were synthesized successfully by coating poly(PEGMA) on the Fe(3)O(4) nanoparticles under UV irradiation, and the Fe(3)O(4) nanoparticles content in this nanogels was above 50 wt%. The morphology, size, zeta-potential and magnetic property were also characterized. The magnetic nanogels had a nearly spherical shape and core-shell structure, the average size in aqueous system measured by photon correlation spectroscopy (PCS) was 68.4 nm, which was much bigger than that in the dry state, the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g, and the zeta-potential was -16.3--17.3 mV at physiological pH (6.8-7.4) which could help to maintain stability in blood. The preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in slow-release. The experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application.
学科主题	Chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000262439700010
公开日期	2012-04-18
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/7803]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Sun, HW,Zhang, LY,Zhu, XJ,et al. Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(1):69.
APA	Sun, HW,Zhang, LY,Zhu, XJ,Kong, CY,Zhang, CL,&Yao, S.(2009).Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(1),69.
MLA	Sun, HW,et al."Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.1(2009):69.