Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation

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	Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation
	Xu, JY ; Li, QN(李晴暖） ; Li, JG ; Ran, TC ; Wu, SW（吴胜伟） ; Song, WM ; Chen, SL ; Li, WX(李文新）
刊名	CARBON
	2007
卷号	45 期号:9 页码:1865
ISSN号	0008-6223
通讯作者	Li, WX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
英文摘要	An increasing number of studies have been devoted to studying the respiratory toxicity of carbon nanomaterials, but little information is known, thus far, on the biodistribution of these nanomaterials after inhalation or intratracheal instillation. We synthesized and labeled a polyhydroxylated derivative of fullerene C-60(OH)(x) (x = 22,24) with Tc-99m. With single photon emission computed tomography imaging and (gamma)-ray counting techniques, the biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation was studied. It was found that, besides the highest retention in the lung, Tc-99m-C-67(OH)(x) is distributed mainly in the liver, bone, and spleen, with no uptake found in brain. The long-term retention in the lung and the very fast clearance from the blood revealed a transient characteristic of penetrating the alveolar-capillary barrier. The dimensions and size distribution, as well as in vivo aggregation of 99mTc-C60(OH)(x),, may affect the capability and kinetic process of penetrating the alveolar-capillary barrier. The results provide guidance for further study of the respiratory toxicity of carbon nanornaterials. (c) 2007 Elsevier Ltd. All rights reserved.
学科主题	Physics
收录类别	SCI
语种	英语
WOS记录号	WOS:000248935500018
公开日期	2012-04-18
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/7664]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Xu, JY,Li, QN,Li, JG,et al. Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation[J]. CARBON,2007,45(9):1865.
APA	Xu, JY.,Li, QN.,Li, JG.,Ran, TC.,Wu, SW.,...&Li, WX.(2007).Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation.CARBON,45(9),1865.
MLA	Xu, JY,et al."Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation".CARBON 45.9(2007):1865.