Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro
	Pei, Ying 1; Chen, Zhen-Ping 1; Ju, Huai-Qiang 1; Komatsu, Masaaki 2; Ji, Yu-hua 3; Liu, Ge 4; Guo, Chao-wan 4; Zhang, Ying-Jun5 ; Yang, Chong-Ren 5; Wang, Yi-Fei 1
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2011-02-11
卷号	405 期号:2 页码:186-191
关键词	Autophagy Pentagalloylglucose (PGG) HSV-1 infections Anti-viral activity
ISSN号	0006-291X
通讯作者	Wang, YF (reprint author), Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
英文摘要	Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7(-/-) cells (autophagy-defective cells) derived from an atg7(-/-) knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro. (C) 2011 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	SIGNALING PATHWAY ; MAMMALIAN TARGET ; CELLS ; PROTEIN ; KINASE ; 1,2,3,4,6-PENTA-O-GALLOYL-BETA-D-GLUCOSE ; INHIBITION ; EXPRESSION ; COMPLEX ; CANCER
收录类别	SCI
资助信息	National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]; Ministry of Education (MOE)[211]; Fundamental Research Funds for the Central Universities; Tokyo Biochemical Research Foundation; Ministry of Education, Culture, Sports, Science and Technology of Japan[22590274]
语种	英语
WOS记录号	WOS:000287627500007
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5569]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China 2.Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan 3.Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China 4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 8528521, Japan 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Pei, Ying,Chen, Zhen-Ping,Ju, Huai-Qiang,et al. Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,405(2):186-191.
APA	Pei, Ying.,Chen, Zhen-Ping.,Ju, Huai-Qiang.,Komatsu, Masaaki.,Ji, Yu-hua.,...&Kitazato, Kaio.(2011).Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,405(2),186-191.
MLA	Pei, Ying,et al."Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 405.2(2011):186-191.