Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
	Zhao, Yu 2; Zhang, Hong-Bin 3; Liu, Ji-Kai 2; Su, Jia 2; Li, Yan2 ; Yao, Zhu-Jun 1; Zhao, Qin-Shi2
刊名	TETRAHEDRON LETTERS
	2011-01-05
卷号	52 期号:1 页码:139-142
关键词	Taxyunnansin A abeo-Taxoids Fragmentation abeo-Paclitaxel Anticancer
ISSN号	0040-4039
通讯作者	Yao, ZJ (reprint author), Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, EISU Chem Biol Div, 345 Lingling Lu, Shanghai 200032, Peoples R China
英文摘要	Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with (t)BuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15 -> 1)-abeo-taxane skeleton with an oxetane ring and pi bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Chemistry
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	BIOLOGICAL EVALUATION ; TAXOL ; SEMISYNTHESIS ; BREVIFOLIOL ; DERIVATIVES ; TAXANE ; CHEMISTRY
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China[20802083, 90813004, 20921091, 21032002]; West Doctor Foundation of CAS[2908026212W1]; Ministry of Science and Technology[2009CB522303, 2010CB833200]; MOH[2009ZX09501]
语种	英语
WOS记录号	WOS:000286789100034
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5559]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, EISU Chem Biol Div, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yu,Zhang, Hong-Bin,Liu, Ji-Kai,et al. Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues[J]. TETRAHEDRON LETTERS,2011,52(1):139-142.
APA	Zhao, Yu.,Zhang, Hong-Bin.,Liu, Ji-Kai.,Su, Jia.,Li, Yan.,...&Zhao, Qin-Shi.(2011).Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues.TETRAHEDRON LETTERS,52(1),139-142.
MLA	Zhao, Yu,et al."Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues".TETRAHEDRON LETTERS 52.1(2011):139-142.