Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway
	Fang, Zhong-Ze 1,2; Nian, Yin2,3 ; Li, Wei 1,2; Wu, Jing-Jing 1; Ge, Guang-Bo 1,2; Dong, Pei-Pei 1,2; Zhang, Yan-Yan 1,2; Qiu, Ming-Hua3 ; Liu, Lei 4; Yang, Ling 1
刊名	PHYTOTHERAPY RESEARCH
	2011
卷号	25 期号:1 页码:17-24
关键词	cycloartane triterpenoids MCF7 p53 apoptosis mitochondrial membrane potential caspase-7
ISSN号	0951-418X
通讯作者	Yang, L (reprint author), Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
英文摘要	The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-beta-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-beta-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-alpha-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 5). The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. The involvement of apoptosis as a major cause of cycloartane triterpenoids-induced cell death was further confirmed. The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. Copyright (C) 2010 John Wiley & Sons, Ltd.
学科主题	Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	EXTRACT INHIBITS PROLIFERATION ; CYTOTOXICITY ; CONSTITUENTS ; GLYCOSIDES ; DAHURICA ; RHIZOMA
收录类别	SCI
资助信息	Ministry of Science and Technology of China[2009CB522808, 2008IM020900]; National Natural Science Foundation of China[30772636]
语种	英语
WOS记录号	WOS:000285848700003
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5447]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 4.Shenzhen Childrens Hosp, Shenzhen 518100, Peoples R China
推荐引用方式 GB/T 7714	Fang, Zhong-Ze,Nian, Yin,Li, Wei,et al. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway[J]. PHYTOTHERAPY RESEARCH,2011,25(1):17-24.
APA	Fang, Zhong-Ze.,Nian, Yin.,Li, Wei.,Wu, Jing-Jing.,Ge, Guang-Bo.,...&Yang, Ling.(2011).Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway.PHYTOTHERAPY RESEARCH,25(1),17-24.
MLA	Fang, Zhong-Ze,et al."Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway".PHYTOTHERAPY RESEARCH 25.1(2011):17-24.