HPLC/ESI-MSn and ESI-MS studies on the Aconitum alkaloids in three Chinese medicinal herbs

	HPLC/ESI-MSn and ESI-MS studies on the Aconitum alkaloids in three Chinese medicinal herbs
	Liu WL ; Pi ZF ; Wang XY ; Song FR ; Liu SY
刊名	journal of separation science
	2010
卷号	33 期号:17-18 页码:2898-2906
关键词	IONIZATION MASS-SPECTROMETRY NORDITERPENOID ALKALOIDS DITERPENOID ALKALOIDS CAPILLARY-ELECTROPHORESIS LIQUID-CHROMATOGRAPHY QUANTITATIVE-ANALYSIS ROOTS MESACONITINE
ISSN号	1615-9306
通讯作者	liu sy
中文摘要	aconitum lipo-alkaloids (ldas) peaks in the previous hplc studies have shown overlapping behavior, making it impossible to identify the total retention behavior of ldas. the structural diversity of ldas in radix aconiti, radix aconiti kusnezoffii and radix aconiti lateralis preparata makes it difficult to synthesize and quantify each of them. therefore, this study has been devoted to develop a hplc/esi-msn method with good resolution of aconitum alkaloids especially ldas and then set up a fast esi-ms sim method to quantify the total contents of specific skeleton ldas in the three herbs via in-source cid and the capability of mass separation. as a result, the retention behavior of ldas was summarized based on an optimized chromatographic separation; 32 alkaloids from the three herbs of aconitum genus were separated and identified according to their fragmentation pathways by using hplc/esi-msn. in addition, a fast quantitative analysis esi-ms sim method was successfully applied to the quantification of the total contents of specific skeleton ldas in the three herbs.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000282612900043
公开日期	2012-04-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43383]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu WL,Pi ZF,Wang XY,et al. HPLC/ESI-MSn and ESI-MS studies on the Aconitum alkaloids in three Chinese medicinal herbs[J]. journal of separation science,2010,33(17-18):2898-2906.
APA	Liu WL,Pi ZF,Wang XY,Song FR,&Liu SY.(2010).HPLC/ESI-MSn and ESI-MS studies on the Aconitum alkaloids in three Chinese medicinal herbs.journal of separation science,33(17-18),2898-2906.
MLA	Liu WL,et al."HPLC/ESI-MSn and ESI-MS studies on the Aconitum alkaloids in three Chinese medicinal herbs".journal of separation science 33.17-18(2010):2898-2906.