Kinetic paths, time scale, and underlying landscapes: A path integral framework to study global natures of nonequilibrium systems and networks

	Kinetic paths, time scale, and underlying landscapes: A path integral framework to study global natures of nonequilibrium systems and networks
	Wang J ; Zhang K ; Wang E
刊名	journal of chemical physics
	2010
卷号	133 期号:12 页码:文献编号：125103
关键词	ENERGY LANDSCAPE DISSIPATION COST GENE-EXPRESSION FALSE VACUUM ROBUSTNESS TRAJECTORIES CONDENSATION ENVIRONMENTS FATE
ISSN号	0021-9606
通讯作者	wang j
中文摘要	we developed a general framework to quantify three key ingredients for dynamics of nonequilibrium systems through path integrals in length space. first, we identify dominant kinetic paths as the ones with optimal weights, leading to effective reduction of dimensionality or degrees of freedom from exponential to polynomial so large systems can be treated. second, we uncover the underlying nonequilibrium potential landscapes from the explorations of the state space through kinetic paths. we apply our framework to a specific example of nonequilibrium network system: lambda phage genetic switch. two distinct basins of attractions emerge. the dominant kinetic paths from one basin to another are irreversible and do not follow the usual steepest descent or gradient path along the landscape. it reflects the fact that the dynamics of nonequilibrium systems is not just determined by potential gradient but also the residual curl flux force, suggesting experiments to test theoretical predictions. third, we have calculated dynamic transition time scales from one basin to another critical for stability of the system through instantons. theoretical predictions are in good agreements with wild type and mutant experiments. we further uncover the correlations between the kinetic transition time scales and the underlying landscape topography: the barrier heights along the dominant paths. we found that both the dominant paths and the landscape are relatively robust against the influences of external environmental perturbations and the system tends to dissipate less with less fluctuations. our general framework can be applied to other nonequilibrium systems. (c) 2010 american institute of physics. [doi: 10.1063/1.3478547]
收录类别	SCI收录期刊论文
语种	英语
公开日期	2012-04-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43354]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang J,Zhang K,Wang E. Kinetic paths, time scale, and underlying landscapes: A path integral framework to study global natures of nonequilibrium systems and networks[J]. journal of chemical physics,2010,133(12):文献编号：125103.
APA	Wang J,Zhang K,&Wang E.(2010).Kinetic paths, time scale, and underlying landscapes: A path integral framework to study global natures of nonequilibrium systems and networks.journal of chemical physics,133(12),文献编号：125103.
MLA	Wang J,et al."Kinetic paths, time scale, and underlying landscapes: A path integral framework to study global natures of nonequilibrium systems and networks".journal of chemical physics 133.12(2010):文献编号：125103.