Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy

doi:10.2217/nnm-2018-0046

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy
	Su, Yanhong 1,2,3; Wang, Kun 3,4; Li, Yong 2; Song, Wenjing 5; Xin, Yongjie 2; Zhao, Wei 2; Tian, Jie3,4 ; Ren, Li 1,5; Lu, Ligong 1,2
刊名	NANOMEDICINE
	2018-05-01
卷号	13 期号:9 页码:1009-1023
关键词	drug delivery hepatocellular carcinoma micelles sorafenib therapy
ISSN号	1743-5889
DOI	10.2217/nnm-2018-0046
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Ren, Li(psliren@scut.edu.cn) ; Lu, Ligong(luligong1969@126.com)
英文摘要	Aim: The clinical application of sorafenib is limited because of its hydrophobicity, low bioavailability and unsatisfying treatment effect. Therefore, sorafenib-loaded PEG-poly (e-caprolactone) micelles (SF micelles) were fabricated for sorafenib delivery. Materials & methods: In vitro assays investigated the solubility, dispersity, stability, cytotoxicity and uptake capacity of SF micelles. In vivo biodistribution and therapeutic effects were studied using HepG2-Luc tumor-bearing mice. Results: SF micelles had a regular spherical structure with good water solubility. In vivo imaging results showed PEG-poly (e-caprolactone) micelles could elevate the sorafenib concentration in tumor tissues. Meanwhile, SF micelles exhibited higher tumor growth inhibition in vivo. Conclusion: SF micelles might be a potential drug delivery system, which could enhance the therapeutic effects of sorafenib.
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0103702] ; National Key Research and Development Program of China[2016YFA0201401] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[21604025] ; National Natural Science Foundation of China[51273072] ; National Natural Science Foundation of China[81701771] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Natural Science Foundation of Guangdong Province, China[2014B090907004] ; Natural Science Foundation of Guangdong Province, China[2016A030310461] ; Science and Technology Foundation of Guangdong Province, China[2013B021800180]
WOS关键词	CANCER-THERAPY ; DRUG-DELIVERY ; CO-DELIVERY ; IN-VIVO ; NANOPARTICLES ; SYSTEM ; CELLS ; DOXORUBICIN ; LIPOSOMES ; NANOPLATFORM
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种	英语
出版者	FUTURE MEDICINE LTD
WOS记录号	WOS:000435412500005
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Science and Technology Foundation of Guangdong Province, China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25832]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Ren, Li; Lu, Ligong
作者单位	1.South China Univ Technol, Sch Med, Guangzhou 510006, Guangdong, Peoples R China 2.Zhuhai Peoples Hosp, Ctr Intervent Radiol, Zhuhai Precis Med Ctr, Zhuhai 519000, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 5.South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Su, Yanhong,Wang, Kun,Li, Yong,et al. Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy[J]. NANOMEDICINE,2018,13(9):1009-1023.
APA	Su, Yanhong.,Wang, Kun.,Li, Yong.,Song, Wenjing.,Xin, Yongjie.,...&Lu, Ligong.(2018).Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy.NANOMEDICINE,13(9),1009-1023.
MLA	Su, Yanhong,et al."Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy".NANOMEDICINE 13.9(2018):1009-1023.