L-Seg: An end-to-end unified framework for multi-lesion segmentation of fundus images | |
Wang, Kai1,2; Guo, Song1,5; Li, Tao1,5; Kang, Hong1,4,5; Li, Ning1,5; Zhang, Yujun3 | |
刊名 | NEUROCOMPUTING |
2019-07-15 | |
卷号 | 349页码:52-63 |
关键词 | Multi-lesion segmentation Fundus image Diabetic retinopathy Class-imbalance |
ISSN号 | 0925-2312 |
DOI | 10.1016/j.neucom.2019.04.019 |
英文摘要 | Diabetic retinopathy and diabetic macular edema are the two leading causes for blindness in working-age people, and the quantitative and qualitative diagnosis of these two diseases usually depends on the presence and areas of lesions in fundus images. The main related lesions include soft exudates, hard exudates, microaneurysms, and haemorrhages. However, segmentation of these four kinds of lesions is difficult due to their uncertainty in size, contrast, and high interclass similarity. Therefore, we aim to design a multi-lesion segmentation model. We have designed the first small object segmentation network (L-Seg) that can segment the four kinds of lesions simultaneously. Taking into account that small lesion regions could not response at high level of network, we propose a multi-scale feature fusion method to handle this problem. In addition, when considering the cases of both class-imbalance and loss-imbalance problems, we propose a multi-channel bin loss. We have evaluated L-Seg on three fundus datasets including two publicly available datasets - IDRiD and e-ophtha and one private dataset - DDR. Extensive experiments have demonstrated that L-Seg achieves better performance in small lesion segmentation than other deep learning models and traditional methods. Specially, the mAUC score of L-Seg is over 16.8%, 1.51% and 3.11% higher than that of DeepLab v3 + on IDRiD, e-ophtha and DDR datasets, respectively. Moreover, our framework shows competitive performance compared with top-3 teams in IDRiD challenge. (C) 2019 Elsevier B. V. All rights reserved. |
资助项目 | National Natural Science Foundation[61872200] ; National Key Research and Development Program of China[2018YFB1003405] ; National Key Research and Development Program of China[2016YFC0400709] ; Natural Science Foundation of Tianjin[18YFYZCG00060] |
WOS研究方向 | Computer Science |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000467536900006 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.204/handle/2XEOYT63/4251] |
专题 | 中国科学院计算技术研究所期刊论文_英文 |
通讯作者 | Wang, Kai |
作者单位 | 1.Nankai Univ, Coll Comp Sci, Tianjin, Peoples R China 2.Key Lab Med Data Anal & Stat Res Tianjin, Tianjin, Peoples R China 3.Chinese Acad, Inst Comp Technol, Beijing, Peoples R China 4.Beijing Shanggong Med Technol Co Ltd, Beijing, Peoples R China 5.Nankai Univ, Tianjin Key Lab Network & Data Secur Technol, Tianjin, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Kai,Guo, Song,Li, Tao,et al. L-Seg: An end-to-end unified framework for multi-lesion segmentation of fundus images[J]. NEUROCOMPUTING,2019,349:52-63. |
APA | Wang, Kai,Guo, Song,Li, Tao,Kang, Hong,Li, Ning,&Zhang, Yujun.(2019).L-Seg: An end-to-end unified framework for multi-lesion segmentation of fundus images.NEUROCOMPUTING,349,52-63. |
MLA | Wang, Kai,et al."L-Seg: An end-to-end unified framework for multi-lesion segmentation of fundus images".NEUROCOMPUTING 349(2019):52-63. |
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