Effect of respiratory guidance on internal/external respiratory motion correlation for synchrotron-based pulsed heavy-ion radiotherapy | |
Xiao, Guoqing4; Ouyang, Shuigen1; Liu, Ruifeng1; He, Pengbo2,3,4; Li, Qiang2,3,4; Wang, Xiaohu1 | |
刊名 | AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE |
2018-09-01 | |
卷号 | 41页码:713-720 |
关键词 | Heavy Ion Radiotherapy Respiratory Motion Personalized Audio-visual Biofeedback Internal/external Motion Consistency |
ISSN号 | 0158-9938 |
DOI | 10.1007/s13246-018-0667-2 |
英文摘要 | Having implemented an audio-visual biofeedback (BFB) method for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery with tracking of external abdominal wall motion, this study evaluated the feasibility of the respiratory guidance method on thoracic and abdominal cancer patients, and the internal/external respiratory motion consistency under respiratory guidance maneuvers due to its interactive intervention in free breathing (FB). A total of 42 breathing traces from seven lung and breast cancer patients and corresponding fluoroscopy movies under FB, standard breath hold (stBH) and representative breath hold (reBH) guidance maneuvers were analyzed. Diaphragm motions were measured manually on a frame-by-frame basis. Mean absolute deviation (MAD) values of the measured external motion curves were calculated for the FB and guidance maneuvers, and the internal/external motion consistencies were compared with a linear fit. Compared with FB, the MAD values were reduced significantly with respiratory guidance maneuvers. The mean internal/external correlations of the first treatment fraction were determined to be 0.96 +/- 0.03, 0.97 +/- 0.02, and 0.97 +/- 0.03 for the FB, stBH and reBH guidance maneuvers, respectively, and were 0.95 +/- 0.03, 0.97 +/- 0.03, and 0.98 +/- 0.02 for the second treatment fraction. No phase shift between the two breathing signals was observed, and good reproducibility of consistency of breathing guidance between the two fractions was achieved. These results demonstrated that treatment precision could be improved for cancer patients with audio-visual BFB, and a strong correlation between diaphragm motion and abdominal wall motion was obtained. The use of audio-visual BFB improved the regularity of both internal and external motions, allowing confident use of the audio-visual BFB method by tracking of the external abdominal wall motion to synchrotron-based heavy-ion radiotherapy. |
资助项目 | National Natural Science Foundation of China[11705247] ; National Key Research and Development Program of the Ministry of Science and Technology of China[2017YFC0107500] ; CAS 'Light of West China' Program[29Y662020] ; Gansu Natural Science Foundation[1606RJZA056] ; National Key Technology Support Program of the Ministry of Science and Technology of China[2015BAI01B11] |
WOS关键词 | Moving Target Irradiation ; Scanned Particle Beams ; Gated Irradiation ; Diaphragm Motion ; Therapy ; System ; Design ; Proton ; Tumors ; Model |
WOS研究方向 | Engineering |
语种 | 英语 |
出版者 | SPRINGER |
WOS记录号 | WOS:000443027000015 |
资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program of the Ministry of Science and Technology of China ; CAS 'Light of West China' Program ; Gansu Natural Science Foundation ; National Key Technology Support Program of the Ministry of Science and Technology of China |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.186/handle/113462/59370] |
专题 | 近代物理研究所_兰州重离子研究装置 |
通讯作者 | Li, Qiang |
作者单位 | 1.Gansu Tumor Hosp, Lanzhou 730050, Gansu, Peoples R China 2.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China |
推荐引用方式 GB/T 7714 | Xiao, Guoqing,Ouyang, Shuigen,Liu, Ruifeng,et al. Effect of respiratory guidance on internal/external respiratory motion correlation for synchrotron-based pulsed heavy-ion radiotherapy[J]. AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE,2018,41:713-720. |
APA | Xiao, Guoqing,Ouyang, Shuigen,Liu, Ruifeng,He, Pengbo,Li, Qiang,&Wang, Xiaohu.(2018).Effect of respiratory guidance on internal/external respiratory motion correlation for synchrotron-based pulsed heavy-ion radiotherapy.AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE,41,713-720. |
MLA | Xiao, Guoqing,et al."Effect of respiratory guidance on internal/external respiratory motion correlation for synchrotron-based pulsed heavy-ion radiotherapy".AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE 41(2018):713-720. |
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