Therapeutic techniques applied in the heavy-ion therapy at IMP

doi:10.1016/j.nimb.2011.01.125

	Therapeutic techniques applied in the heavy-ion therapy at IMP
	Sihver, Lembit 2,3,5; Li, Qiang1,4
刊名	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
	2011-04-01
卷号	269 页码:664-670
关键词	Heavy-ion therapy Therapy terminal Beam delivery Treatment planning Patient treatment
ISSN号	0168-583X
DOI	10.1016/j.nimb.2011.01.125
英文摘要	Superficially-placed tumors have been treated with carbon ions at the Institute of Modern Physics (IMP), Chinese Academy of Sciences (CAS), since November 2006. Up to now, 103 patients have been irradiated in the therapy terminal of the heavy ion research facility in Lanzhou (HIRFL) at IMP, where carbon-ion beams with energies up to 100 MeV/u can be supplied and a passive beam delivery system has been developed and commissioned. A number of therapeutic and clinical experiences concerning heavy-ion therapy have been acquired at IMP. To extend the heavy-ion therapy project to deep-seated tumor treatment, a horizontal beam line dedicated to this has been constructed in the cooling storage ring (CSR), which is a synchrotron connected to the HIRFL as an injector, and is now in operation. Therapeutic high-energy carbon-ion beams, extracted from the HIRFL-CSR through slow extraction techniques, have been supplied in the deep-seated tumor therapy terminal. After the beam delivery, shaping and monitoring devices installed in the therapy terminal at HIRFL-CSR were validated through therapeutic beam tests, deep-seated tumor treatment with high-energy carbon ions started in March 2009. The therapeutic techniques in terms of beam delivery system, conformal irradiation method and treatment planning used at IMP are introduced in this paper. (C) 2011 Elsevier B.V. All rights reserved.
资助项目	National Basic Research Program of China (973 Program)[2010CB834203] ; National Natural Science Foundation of China[10835011] ; National Natural Science Foundation of China[10905080] ; National Natural Science Foundation of China[11075191] ; Science and Technology Development Project of Lanzhou City[2008-sr-10] ; Science and Technology Development Project of Lanzhou City[2009-2-12] ; K.C.Wong Education Foundation, Hong Kong
WOS关键词	BEAM 3-DIMENSIONAL IRRADIATION ; MICRODOSIMETRIC-KINETIC-MODEL ; LOCAL EFFECT MODEL ; CELL-SURVIVAL ; CONFORMAL IRRADIATION ; PARTICLE THERAPY ; LIQUID WATER ; RADIOTHERAPY ; RADIATION ; SYSTEM
WOS研究方向	Instruments & Instrumentation ; Nuclear Science & Technology ; Physics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000289183000007
资助机构	National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Science and Technology Development Project of Lanzhou City ; K.C.Wong Education Foundation, Hong Kong
内容类型	期刊论文
源URL	[http://ir.impcas.ac.cn/handle/113462/18590]
专题	近代物理研究所_医学物理研究室近代物理研究所_生物物理研究室
通讯作者	Li, Qiang
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Roanoke Coll, Salem, VA 24153 USA 3.Chalmers, SE-41296 Gothenburg, Sweden 4.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 5.Texas A&M Univ, College Stn, TX 77843 USA
推荐引用方式 GB/T 7714	Sihver, Lembit,Li, Qiang. Therapeutic techniques applied in the heavy-ion therapy at IMP[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2011,269:664-670.
APA	Sihver, Lembit,&Li, Qiang.(2011).Therapeutic techniques applied in the heavy-ion therapy at IMP.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,269,664-670.
MLA	Sihver, Lembit,et al."Therapeutic techniques applied in the heavy-ion therapy at IMP".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 269(2011):664-670.