Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells

doi:10.1016/j.ejmp.2013.12.001

	Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells
	Jia, QT 3; Hasan, M 3; Lin, FK 3; Wang, R 3; Ran, YY 3; Qing, H (reprint author), Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China.; Qing, H 3; Deng, YL 3; Li, Q3 ; Wang, X 3
刊名	PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
	2014
卷号	30 页码:427-431
关键词	Dna-damage Ionizing-radiation Antioxidants Induction
ISSN号	1120-1797
DOI	10.1016/j.ejmp.2013.12.001
英文摘要	Purpose: The radioprotective effects of Dragon's blood ( DB) and its extracts (DBE) were investigated using the chromosomal aberrant test, micronucleus and oxidative stress assay for anti-clastogenic and anti-oxidative activity. Materials and methods: Adult BALB/C mice were exposed to the whole body irradiation with 4 Gy Co-60 gamma rays. DB and DBE were administered orally once a day from 5 days prior to irradiation treatment to 1 day after irradiation. The mice were sacrificed on 24 h after irradiation. The cells of bone marrow were measured by counting different types of chromosomal aberrations and the frequency of micronuclei. Oxidative stress response was carried out by analysis of serum from blood. Results: DB and DBE significantly decreased the number of bone marrow cells with chromosome aberrations after irradiation with respect to irradiated alone group. The administration of DB and DBE also significantly reduced the frequencies of micronucleated polychromatic erythrocytes ( MPCE) and micronucleated normochromatic erythrocytes ( MNCE). In addition, DB and DBE markedly increased the activity of antioxidant enzymes and the level of antioxidant molecular. Malondialdehyde ( MDA) and nitric oxide ( NO) levels in serum were significantly reduced by DB and DBE treatment. Conclusions: Our data suggested that DB and DBE have potential radioprotective properties in mouse bone marrow after Co-60 gamma-ray exposure, which support their candidature as a potential radioprotective agent. (c) 2013 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
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资助项目	Natural Science Foundation of China[81171206]
WOS关键词	DNA-DAMAGE ; IONIZING-RADIATION ; ANTIOXIDANTS ; INDUCTION
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000335393200005
资助机构	Ministry of Science and Technology [2006BAI06A18-16, 2012YQ040140] ; Ministry of Science and Technology [2006BAI06A18-16, 2012YQ040140] ; Natural Science Foundation of China [81171206] ; Natural Science Foundation of China [81171206]
内容类型	期刊论文
源URL	[http://ir.impcas.ac.cn/handle/113462/18580]
专题	近代物理研究所_医学物理研究室近代物理研究所_生物物理研究室
通讯作者	Qing, H (reprint author), Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China.
作者单位	1.Guo, Yong] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Shao, Shijun 3.[Cao, Linying 4.[Cao, Linying] Univ Chinese Acad Sci, Beijing 100039, Peoples R China 5.[Cao, Linying 6.Shao, Shijun 7.Guo, Yong] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 8.[Wu, Qingfeng 9.Li, Qiang] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Jia, QT,Hasan, M,Lin, FK,et al. Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells[J]. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,2014,30:427-431.
APA	Jia, QT.,Hasan, M.,Lin, FK.,Wang, R.,Ran, YY.,...&Tang, B.(2014).Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells.PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,30,427-431.
MLA	Jia, QT,et al."Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells".PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 30(2014):427-431.