Simulations to design an online motion compensation system for scanned particle beams

doi:10.1088/0031-9155/51/14/016

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 近代物理研究所知识存储（2010之前）

	Simulations to design an online motion compensation system for scanned particle beams
	Groezinger, Sven Oliver ; Rietzel, Eike ; Li, Qiang ; Bert, Christoph; Haberer, Thomas ; Kraft, Gerhard
刊名	PHYSICS IN MEDICINE AND BIOLOGY
	2006-07-21
卷号	51 期号:14 页码:3517-3531
ISSN号	0031-9155
DOI	10.1088/0031-9155/51/14/016
英文摘要	Respiration-induced target motion is a major problem in intensity-modulated radiation therapy. Beam segments are delivered serially to form the total dose distribution. In the presence of motion, the spatial relation between dose deposition from different segments will be lost. Usually, this results in over-and underdosage. Besides such interplay effects between target motion and dynamic beam delivery as known from photon therapy, changes in internal density have an impact on delivered dose for intensity-modulated charged particle therapy. In this study, we have analysed interplay effects between raster scanned carbon ion beams and target motion. Furthermore, the potential of an online motion strategy was assessed in several simulations. An extended version of the clinical treatment planning software was used to calculate dose distributions to moving targets with and without motion compensation. For motion compensation, each individual ion pencil beam tracked the planned target position in the lateral aswell as longitudinal direction. Target translations and rotations, including changes in internal density, were simulated. Target motion simulating breathing resulted in severe degradation of delivered dose distributions. For example, for motion amplitudes of +/- 15 mm, only 47% of the target volume received 80% of the planned dose. Unpredictability of resulting dose distributions was demonstrated by varying motion parameters. On the other hand, motion compensation allowed for dose distributions for moving targets comparable to those for static targets. Even limited compensation precision (standard deviation similar to 2 mm), introduced to simulate possible limitations of real-time target tracking, resulted in less than 3% loss in dose homogeneity.
WOS关键词	ORGAN MOTION ; RESPIRATORY MOTION ; CONFORMAL RADIOTHERAPY ; TARGET VOLUME ; SET-UP ; TUMOR ; TRACKING ; THERAPY ; DELIVERY ; CANCER
WOS研究方向	Engineering ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000238945700017
公开日期	2010-10-29
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/6177]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）
通讯作者	Groezinger, Sven Oliver
作者单位	1.GSI Darmstadt, D-64291 Darmstadt, Germany 2.Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02114 USA 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Groezinger, Sven Oliver,Rietzel, Eike,Li, Qiang,et al. Simulations to design an online motion compensation system for scanned particle beams[J]. PHYSICS IN MEDICINE AND BIOLOGY,2006,51(14):3517-3531.
APA	Groezinger, Sven Oliver,Rietzel, Eike,Li, Qiang,Bert, Christoph,Haberer, Thomas,&Kraft, Gerhard.(2006).Simulations to design an online motion compensation system for scanned particle beams.PHYSICS IN MEDICINE AND BIOLOGY,51(14),3517-3531.
MLA	Groezinger, Sven Oliver,et al."Simulations to design an online motion compensation system for scanned particle beams".PHYSICS IN MEDICINE AND BIOLOGY 51.14(2006):3517-3531.