Micro Insert: A Prototype Full-Ring PET Device for Improving the Image Resolution of a Small-Animal PET Scanner

doi:10.2967/jnumed.107.050070

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 近代物理研究所知识存储（2010之前）

	Micro Insert: A Prototype Full-Ring PET Device for Improving the Image Resolution of a Small-Animal PET Scanner
	Wu, Heyu 2,3; Pal, Debashish 4; Song, Tae Yong 2; O'Sullivan, Joseph A.5; Tai, Yuan-Chuan 1,2
刊名	JOURNAL OF NUCLEAR MEDICINE
	2008-10-01
卷号	49 期号:10 页码:1668-1676
关键词	small-animal PET high-resolution PET PET insert animal imaging
ISSN号	0161-5505
DOI	10.2967/jnumed.107.050070
英文摘要	A full-ring PET insert device should be able to enhance the image resolution of existing small-animal PET scanners. Methods: The device consists of 18 high-resolution PET detectors in a cylindric enclosure. Each detector contains a cerium-doped lutetium oxyorthosilicate array (12 x 12 crystals, 0.72 x 1.51 x 3.75 mm each) coupled to a position-sensitive photomultiplier tube via an optical fiber bundle made of 8 x 16 square multiclad fibers. Signals from the insert detectors are connected to the scanner through the electronics of the disabled first ring of detectors, which permits coincidence detection between the 2 systems. Energy resolution of a detector was measured using a Ge-68 point source, and a calibrated 68Ge point source stepped across the axial field of view (FOV) provided the sensitivity profile of the system. A Na-22 point source imaged at different offsets from the center characterized the in-plane resolution of the insert system. Imaging was then performed with a Derenzo phantom filled with 19.5 MBq of F-18-fluoride and imaged for 2 h; a 24.3-g mouse injected with 129.5 MBq of F-18-fluoride and imaged in 5 bed positions at 3.5 h after injection; and a 22.8-g mouse injected with 14.3 MBq of F-18-FDG and imaged for 2 h with electrocardiogram gating. Results: The energy resolution of a typical detector module at 511 keV is 19.0% +/- 3.1 %. The peak sensitivity of the system is approximately 2.67%. The image resolution of the system ranges from 1.0- to 1.8-mm full width at half maximum near the center of the FOV, depending on the type of coincidence events used for image reconstruction. Derenzo phantom and mouse bone images showed significant improvement in transaxial image resolution using the insert device. Mouse heart images demonstrated the gated imaging capability of the device. Conclusion: We have built a prototype full-ring insert device for a small-animal PET scanner to provide higher-resolution PET images within a reduced imaging FOV. Development of additional correction techniques are needed to achieve quantitative imaging with such an insert.
资助项目	National Cancer Institute of the National Institutes of Health[R24-CA83060] ; National Cancer Institute of the National Institutes of Health[R33-CA-110011] ; National Cancer Institute of the National Institutes of Health[P30-CA91842] ; Susan G. Komen for the Cure[BCTR0601279]
WOS关键词	POSITRON EMISSION TOMOGRAPH ; SPATIAL-RESOLUTION ; DESIGN ; PERFORMANCE ; SYSTEM
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SOC NUCLEAR MEDICINE INC
WOS记录号	WOS:000260229900046
资助机构	National Cancer Institute of the National Institutes of Health ; Susan G. Komen for the Cure
公开日期	2010-10-29
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/5537]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）
通讯作者	Tai, Yuan-Chuan
作者单位	1.Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA 2.Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 4.Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA 5.Washington Univ, Dept Elect & Syst Engn, St Louis, MO 63110 USA
推荐引用方式 GB/T 7714	Wu, Heyu,Pal, Debashish,Song, Tae Yong,et al. Micro Insert: A Prototype Full-Ring PET Device for Improving the Image Resolution of a Small-Animal PET Scanner[J]. JOURNAL OF NUCLEAR MEDICINE,2008,49(10):1668-1676.
APA	Wu, Heyu,Pal, Debashish,Song, Tae Yong,O'Sullivan, Joseph A.,&Tai, Yuan-Chuan.(2008).Micro Insert: A Prototype Full-Ring PET Device for Improving the Image Resolution of a Small-Animal PET Scanner.JOURNAL OF NUCLEAR MEDICINE,49(10),1668-1676.
MLA	Wu, Heyu,et al."Micro Insert: A Prototype Full-Ring PET Device for Improving the Image Resolution of a Small-Animal PET Scanner".JOURNAL OF NUCLEAR MEDICINE 49.10(2008):1668-1676.