Autophagy-regulating microRNAs: potential targets for improving radiotherapy

doi:10.1007/s00432-018-2675-8

	Autophagy-regulating microRNAs: potential targets for improving radiotherapy
	Li, Hongbin 1,2,3,4; Jin, Xiaodong1,2,3 ; Chen, Bing 5; Li, Ping1,2,3 ; Li, Qiang1,2,3
刊名	JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
	2018-09-01
卷号	144 页码:1623-1634
关键词	MicroRNAs Autophagy Ionizing radiation Radioresistance Radiosensitivity Radiotherapy
ISSN号	0171-5216
DOI	10.1007/s00432-018-2675-8
英文摘要	Radiotherapy (RT) is one of the most important therapeutic strategies against cancer. However, resistance of cancer cells to radiation remains a major challenge for RT. Thus, novel strategies to overcome cancer cell radioresistance are urgent. Macroautophagy (hereafter referred to as autophagy) is a biological process by which damaged cell components can be removed and accordingly represent a cytoprotective mechanism. Because radiation-induced autophagy is associated with either cell death or radioresistance of cancer cells, a deeper understanding of the autophagy mechanism triggered by radiation will expedite a development of strategies improving the efficacy of RT. MicroRNAs (miRNAs) are involved in many biological processes. Mounting evidence indicates that many miRNAs are involved in regulation of the autophagic process induced by radiation insult, but the underlying mechanisms remain obscure. Therefore, a deep understanding of the mechanisms of miRNAs in regulating autophagy and radioresistance will provide a new perspective for RT against cancer. We summarized the recent pertinent literature from various electronic databases, including PubMed. We reviewed the radiation-induced autophagy response and its association of the role, function and regulation of miRNAs, and discussed the feasibility of targeting autophagy-related miRNAs to improve the efficacy of RT. The beneficial or harmful effect of autophagy may depend on the types of cancer and stress. The cytoprotective role of autophagy plays a dominant role in cancer RT. For most tumor cells, reducing radiation-induced autophagy can improve the efficacy of RT. MiRNAs have been confirmed to take part in the autophagy regulatory network of cancer RT, the autophagy-regulating miRNAs therefore could be developed as potential targets for improving RT.
资助项目	National Key Research Program of China[2016YFC0904700] ; National Key Research Program of China[2016YFC0904702] ; NSFC-CAS Joint Fund for Research Based on Large-scaled Scientific Facilities[U1532264] ; National Natural Science Foundation of China[11305223] ; National Natural Science Foundation of China[11505245] ; Western Talents Program of the Chinese Academy of Sciences[Y562020XB0]
WOS关键词	BREAST-CANCER CELLS ; RADIATION-INDUCED AUTOPHAGY ; NASOPHARYNGEAL CARCINOMA-CELLS ; HUMAN GLIOBLASTOMA CELLS ; DOSE IONIZING-RADIATION ; LUNG-CANCER ; PROSTATE-CANCER ; NONCODING RNAS ; ENHANCES RADIOSENSITIVITY ; SUPPRESSES AUTOPHAGY
WOS研究方向	Oncology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000440283600001
资助机构	National Key Research Program of China ; NSFC-CAS Joint Fund for Research Based on Large-scaled Scientific Facilities ; National Natural Science Foundation of China ; Western Talents Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/59190]
专题	中国科学院近代物理研究所
作者单位	1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongbin,Jin, Xiaodong,Chen, Bing,et al. Autophagy-regulating microRNAs: potential targets for improving radiotherapy[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2018,144:1623-1634.
APA	Li, Hongbin,Jin, Xiaodong,Chen, Bing,Li, Ping,&Li, Qiang.(2018).Autophagy-regulating microRNAs: potential targets for improving radiotherapy.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,144,1623-1634.
MLA	Li, Hongbin,et al."Autophagy-regulating microRNAs: potential targets for improving radiotherapy".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 144(2018):1623-1634.