The hyper-radiosensitivity effect of human hepatoma SMMC-7721 cells exposed to low dose gamma-rays and C-12 ions

doi:10.1016/j.nimb.2005.11.120

	The hyper-radiosensitivity effect of human hepatoma SMMC-7721 cells exposed to low dose gamma-rays and C-12 ions
	Jin, XD; Li, Q; Li, WJ; Wang, JF; Guo, CL; Hao, JF
	2006-04
关键词	hyper-radiosensitivity increased radio-resistance cell sorter surviving fraction high-LET
卷号	245
期号	1
DOI	10.1016/j.nimb.2005.11.120
页码	310-313
英文摘要	Hypersensitive response of mammalian cells in cell killing to X- and gamma-rays has been reported at doses below 1 Gy. The purpose of this study was to examine the low dose sensitivity of human hepatoma SMMC-7721 cells irradiated with Co-60 gamma-rays and 50 MeV/u C-12 ions. Experiments using gamma-rays and charged particle irradiation were performed, particularly in the low dose range from 0 to 2 Gy. The survival effect of SMMC-7721 cells was measured by means of standard clonogenic assay in conjunction with a cell sorter. The result indicates SMMC-7721 cells showed hyper-radiosensitive response at low doses and increased radio-resistance at larger single doses for the carbon ions (LET = 45.2 keV/mu m) and the gamma-rays. However, the HRS/IRR effect caused by high-LET irradiation is different from that by low-LET radiation. This might possibly be due to the difference in the mode of energy deposition by particle beam and low-LET irradiation. (c) 2005 Elsevier B.V. All rights reserved.
会议录	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
会议录出版者	ELSEVIER SCIENCE BV
会议录出版地	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
语种	英语
WOS研究方向	Instruments & Instrumentation ; Nuclear Science & Technology ; Physics
WOS记录号	WOS:000236288500068
内容类型	会议论文
源URL	[http://119.78.100.186/handle/113462/57628]
专题	中国科学院近代物理研究所
通讯作者	Jin, XD
作者单位	Chinese Acad Sci, Grad Sch, Beijing 100040, Peoples R China
推荐引用方式 GB/T 7714	Jin, XD,Li, Q,Li, WJ,et al. The hyper-radiosensitivity effect of human hepatoma SMMC-7721 cells exposed to low dose gamma-rays and C-12 ions[C]. 见:.