Oscillatory expression and variability in p53 regulatory network

doi:10.1016/j.physd.2010.09.004

	Oscillatory expression and variability in p53 regulatory network
	Liu, Bo 1; Yan, Shiwei 1,2,3; Wang, Qi 1; Liu, Shengjun 1
刊名	PHYSICA D-NONLINEAR PHENOMENA
	2011-02
卷号	240 页码:259-264
关键词	Cancer genetics Master equation Nonlinear feedback p53-Mdm2 system
ISSN号	0167-2789
DOI	10.1016/j.physd.2010.09.004
英文摘要	The effect of delay, nonlinearity and noise on oscillatory motion is of permanent interest for theoretical and experimental research. Here we explore a negative feedback loop between p53 and Mdm2 with a time delay, which is a key circuit in the response of cells to damage. This circuit shows noisy sustained oscillations in individual human cells following DNA damage, and damped oscillations at the cell population level. We demonstrate the effect of delay on the oscillation, and the correlation in time course. In a multi-species system, the events at different time points which span a time delay are coupled even when the delay is large compared with the other characteristic times of the system. We also clarify that the dynamics at the single-cell level appears to be coherent resonance, and the origin of the damped oscillation at the macroscopic level out of the sustained ones at the single-cell level can be ascribed to the dephasing process which is induced by the interplay between nonlinearity and noise. The findings are consistent with experimental observations and advance our understanding of the dynamics of the p53 network. (C) 2010 Elsevier B.V. All rights reserved.
资助项目	Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China[MOP2006138]
WOS关键词	P53-MDM2 FEEDBACK LOOP ; BIOLOGICAL NETWORKS ; TIME-DELAY ; SIMULATION ; DYNAMICS ; CELLS ; MODEL
WOS研究方向	Mathematics ; Physics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000287342900002
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/56983]
专题	中国科学院近代物理研究所
通讯作者	Yan, Shiwei
作者单位	1.Beijing Normal Univ, Coll Nucl Sci & Technol, Beijing 100875, Peoples R China 2.Beijing Radiat Ctr, Beijing 100875, Peoples R China 3.Natl Lab Heavy Ion Accelerator Lanzhou, Ctr Theoret Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Bo,Yan, Shiwei,Wang, Qi,et al. Oscillatory expression and variability in p53 regulatory network[J]. PHYSICA D-NONLINEAR PHENOMENA,2011,240:259-264.
APA	Liu, Bo,Yan, Shiwei,Wang, Qi,&Liu, Shengjun.(2011).Oscillatory expression and variability in p53 regulatory network.PHYSICA D-NONLINEAR PHENOMENA,240,259-264.
MLA	Liu, Bo,et al."Oscillatory expression and variability in p53 regulatory network".PHYSICA D-NONLINEAR PHENOMENA 240(2011):259-264.