CORC  > 近代物理研究所  > 中国科学院近代物理研究所
Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells
Liu, Yuanyuan1,2,3; Liu, Yang1,2,3; Zhang, Hong1,2,3; Sun, Chao1,2,3; Zhao, Qiuyue1,2,3; Di, Cixia1,2,3; Li, Hongyan1,2,3; Gan, Lu1,2,3; Wang, Yali4
刊名CELL BIOLOGY INTERNATIONAL
2014-11-01
卷号38页码:1304-1310
关键词Angiogenesis Bfgf Carbon-ion Irradiation Lung Adenocarcinoma Cells Vegf
ISSN号1065-6995
DOI10.1002/cbin.10327
文献子类Article
英文摘要Radiotherapy has been focused mainly on killing cancer cells, and little attention has been paid to the process supporting tumor growth and metastasis, including the process of angiogenesis. To investigate the effects of carbon-ion irradiation on angiogenesis in lung cancer cells, we examined the expression of vascular endothelial growth factor and basic fibroblast growth factor in the tumor conditioned medium (TCM) of A549 cells exposed to carbon-ion or X-ray irradiation, as well as endothelial cell growth, invasion, and tube formation induced by TCM. No changes in vascular endothelial growth factor secretion were detected in the TCM of A549 cells exposed to carbon-ion irradiation at 2 or 4Gy, whereas 1Gy of irradiation significantly decreased vascular endothelial growth factor and basic fibroblast growth factor levels. Carbon-ion irradiation at 1Gy inhibited endothelial cell invasion and tube formation. The TCM from A549 cells irradiated with X-ray promoted angiogenesis, whereas the TCM of A549 cells exposed to carbon-ion irradiation at 2 or 4Gy had no effect. These findings suggest that carbon-ion irradiation at 1Gy significantly suppressed the process of angiogenesis in vitro by inhibiting endothelial cell invasion and tube formation, which are related to vascular endothelial growth factor and basic fibroblast growth factor production.
资助项目Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Scientific Technology Research Projects of Gansu Province[0806RJYA020]
WOS关键词ENDOTHELIAL GROWTH-FACTOR ; LYMPHOCYTE-INDUCED ANGIOGENESIS ; PROGNOSTIC-SIGNIFICANCE ; FACTOR EXPRESSION ; BREAST-CARCINOMA ; CANCER ; VEGF ; SURVIVAL ; RADIATION ; APOPTOSIS
WOS研究方向Cell Biology
语种英语
出版者WILEY-BLACKWELL
WOS记录号WOS:000342798200009
内容类型期刊论文
源URL[http://119.78.100.186/handle/113462/49769]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China
4.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yuanyuan,Liu, Yang,Zhang, Hong,et al. Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells[J]. CELL BIOLOGY INTERNATIONAL,2014,38:1304-1310.
APA Liu, Yuanyuan.,Liu, Yang.,Zhang, Hong.,Sun, Chao.,Zhao, Qiuyue.,...&Wang, Yali.(2014).Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells.CELL BIOLOGY INTERNATIONAL,38,1304-1310.
MLA Liu, Yuanyuan,et al."Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells".CELL BIOLOGY INTERNATIONAL 38(2014):1304-1310.
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace