Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells

doi:10.1002/cbin.10327

	Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells
	Liu, Yuanyuan1,2,3 ; Liu, Yang1,2,3 ; Zhang, Hong1,2,3 ; Sun, Chao 1,2,3; Zhao, Qiuyue 1,2,3; Di, Cixia 1,2,3; Li, Hongyan 1,2,3; Gan, Lu1,2,3 ; Wang, Yali 4
刊名	CELL BIOLOGY INTERNATIONAL
	2014-11-01
卷号	38 页码:1304-1310
关键词	Angiogenesis Bfgf Carbon-ion Irradiation Lung Adenocarcinoma Cells Vegf
ISSN号	1065-6995
DOI	10.1002/cbin.10327
文献子类	Article
英文摘要	Radiotherapy has been focused mainly on killing cancer cells, and little attention has been paid to the process supporting tumor growth and metastasis, including the process of angiogenesis. To investigate the effects of carbon-ion irradiation on angiogenesis in lung cancer cells, we examined the expression of vascular endothelial growth factor and basic fibroblast growth factor in the tumor conditioned medium (TCM) of A549 cells exposed to carbon-ion or X-ray irradiation, as well as endothelial cell growth, invasion, and tube formation induced by TCM. No changes in vascular endothelial growth factor secretion were detected in the TCM of A549 cells exposed to carbon-ion irradiation at 2 or 4Gy, whereas 1Gy of irradiation significantly decreased vascular endothelial growth factor and basic fibroblast growth factor levels. Carbon-ion irradiation at 1Gy inhibited endothelial cell invasion and tube formation. The TCM from A549 cells irradiated with X-ray promoted angiogenesis, whereas the TCM of A549 cells exposed to carbon-ion irradiation at 2 or 4Gy had no effect. These findings suggest that carbon-ion irradiation at 1Gy significantly suppressed the process of angiogenesis in vitro by inhibiting endothelial cell invasion and tube formation, which are related to vascular endothelial growth factor and basic fibroblast growth factor production.
资助项目	Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Scientific Technology Research Projects of Gansu Province[0806RJYA020]
WOS关键词	ENDOTHELIAL GROWTH-FACTOR ; LYMPHOCYTE-INDUCED ANGIOGENESIS ; PROGNOSTIC-SIGNIFICANCE ; FACTOR EXPRESSION ; BREAST-CARCINOMA ; CANCER ; VEGF ; SURVIVAL ; RADIATION ; APOPTOSIS
WOS研究方向	Cell Biology
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000342798200009
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/49769]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yuanyuan,Liu, Yang,Zhang, Hong,et al. Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells[J]. CELL BIOLOGY INTERNATIONAL,2014,38:1304-1310.
APA	Liu, Yuanyuan.,Liu, Yang.,Zhang, Hong.,Sun, Chao.,Zhao, Qiuyue.,...&Wang, Yali.(2014).Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells.CELL BIOLOGY INTERNATIONAL,38,1304-1310.
MLA	Liu, Yuanyuan,et al."Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells".CELL BIOLOGY INTERNATIONAL 38(2014):1304-1310.