y Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo

doi:10.3390/ijms161226109

	y Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo
	Lei, Runhong 1; Zhao, Tuo 1; Li, Qiang2 ; Wang, Xiao 3; Ma, Hong 1; Deng, Yulin 1
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2015-12-01
卷号	16 页码:28334-28346
关键词	carbon ions neural injury peripheral immune system side effects T-cell development
ISSN号	1422-0067
DOI	10.3390/ijms161226109
英文摘要	Carbon ion radiation is a promising treatment for brain cancer; however, the immune system involved long-term systemic effects evoke a concern of complementary and alternative therapies in clinical treatment. To clarify radiotherapy caused fundamental changes in peripheral immune system, examinations were performed based on established models in vitro and in vivo. We found that brain-localized carbon ion radiation of neural cells induced complex changes in the peripheral blood, thymus, and spleen at one, two, and three months after its application. Atrophy, apoptosis, and abnormal T-cell distributions were observed in rats receiving a single high dose of radiation. Radiation downregulated the expression of proteins involved in T-cell development at the transcriptional level and increased the proportion of CD3(+)CD4(-)CD8(+) T-cells in the thymus and the proportion of CD3(+)CD4(+)CD8(-) T-cells in the spleen. These data show that brain irradiation severely affects the peripheral immune system, even at relatively long times after irradiation. In addition, they provide valuable information that will implement the design of biological-based strategies that will aid brain cancer patients suffering from the long-term side effects of radiation.
资助项目	Ministry of Science and Technology, Beijing, China[2012YQ040140] ; Ministry of Science and Technology, Beijing, China[2012YQ12004410] ; National Natural Science Foundation of China[31200636]
WOS关键词	FRACTIONATED STEREOTACTIC RADIOTHERAPY ; THYMOCYTE HOMEOSTASIS ; RADIATION-THERAPY ; BRAIN-TUMORS ; SKULL BASE ; T-CELLS ; RECEPTOR ; DISEASE ; THYMUS ; RAT
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000367535600027
资助机构	Ministry of Science and Technology, Beijing, China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/41348]
专题	中国科学院近代物理研究所
通讯作者	Ma, Hong
作者单位	1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.China Inst Atom Energy, Dept Nucl Phys, Beijing 102413, Peoples R China
推荐引用方式 GB/T 7714	Lei, Runhong,Zhao, Tuo,Li, Qiang,et al. y Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16:28334-28346.
APA	Lei, Runhong,Zhao, Tuo,Li, Qiang,Wang, Xiao,Ma, Hong,&Deng, Yulin.(2015).y Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16,28334-28346.
MLA	Lei, Runhong,et al."y Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16(2015):28334-28346.