HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells

doi:10.1111/cas.13657

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院强磁场科学中心

	HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells
	Zhang, Rui 1,2; Wang, Jun1
刊名	CANCER SCIENCE
	2018-08-01
卷号	109 期号:8 页码:2446-2457
关键词	ATM p38 signaling HuR mRNA stability radiosensitivity TFAM
ISSN号	1349-7006
DOI	10.1111/cas.13657
通讯作者	Wang, Jun(wangjun0457@ipp.ac.cn)
英文摘要	Mitochondrial transcription factor A (TFAM) plays key roles in transcription and maintenance of mtDNA. It has been reported that TFAM could promote the proliferation and tumorigenesis of cells under stressed conditions. Previous evidence showed ionizing radiation stimulated the expression of TFAM, the replication of mtDNA, and the activity of mtDNA-encoded cytochrome C oxidase. However, little is known about the mechanism of TFAM regulation in irradiated cells. In this article, we explored the role of mRNA stability in regulating TFAM expression in irradiated cancer cells. Our results showed that radiation stimulated the levels of TFAM mRNA and protein. RNA-binding protein HuR associated and stabilized TFAM mRNA to facilitate the expression of TFAM, which was enhanced by radiation. Furthermore, radiation-activated ataxia-telangiectasia mutated kinase/p38 signaling positively contributed to the nucleus to cytosol translocation of HuR, its binding and stabilization of TFAM mRNA, without affecting the transcription and the stability of TFAM. Our current work proposed a new mechanism of DNA damage response-regulated mitochondrial function variations, and indicated that TFAM might be a potential target for increasing the sensitization of cancer cells to radiotherapy.
资助项目	International Thermonuclear Experimental Reactor program ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Development Foundation of Hefei Center for Physical Science and Technology
WOS关键词	MITOCHONDRIAL TRANSCRIPTION FACTOR ; BINDING PROTEIN HUR ; DNA-DAMAGE ; COLORECTAL-CANCER ; OXIDATIVE STRESS ; LUNG-CANCER ; A549 CELLS ; BIOGENESIS ; EXPRESSION ; PHOSPHORYLATION
WOS研究方向	Oncology
语种	英语
出版者	WILEY
WOS记录号	WOS:000442985500012
资助机构	International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; 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Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; 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International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; International Thermonuclear Experimental Reactor program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology ; Development Foundation of Hefei Center for Physical Science and Technology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/38103]
专题	合肥物质科学研究院_中科院强磁场科学中心
通讯作者	Wang, Jun
作者单位	1.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Rui,Wang, Jun. HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells[J]. CANCER SCIENCE,2018,109(8):2446-2457.
APA	Zhang, Rui,&Wang, Jun.(2018).HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.CANCER SCIENCE,109(8),2446-2457.
MLA	Zhang, Rui,et al."HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells".CANCER SCIENCE 109.8(2018):2446-2457.