A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties | |
Wang, Jiarong1,2; Ma, Kun1,2; Ruan, Maosen1,2; Wang, Yujuan1,2; Li, Yan1,2,3; Fu, Yu, V4; Song, Yonghong5; Sun, Hongbin1,2,6; Wang, Junfeng1,2,7 | |
刊名 | PEERJ |
2018-07-25 | |
卷号 | 6页码:21 |
关键词 | Cecropin DH Antibacterial activity LPS small micelle formation Inhibition of pro-inflammatory cytokines |
ISSN号 | 2167-8359 |
DOI | 10.7717/peerj.5369 |
通讯作者 | Sun, Hongbin(hbsun@hmfl.ac.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn) |
英文摘要 | Cecropins, originally found in insects, are a group of cationic antimicrobial peptides. Most cecropins have an amphipathic N-terminal segment and a largely hydrophobic C-terminal segment, and normally form a helix-hinge-helix structure. In this study, we developed the novel 32-residue cecropin-like peptide cecropin DH by deleting the hinge region (Alanine-Glycine-Proline) of cecropin B isolated from Chinese oak silk moth, Antheraea pernyi. Cecropin DH possesses effective antibacterial activity, particularly against Gram-negative bacteria, with very low cytotoxicity against mammalian cells. Interactions between cecropin DH and the highly anionic lipopolysaccharide (LPS) component of the Gram-negative bacterial outer membrane indicate that it is capable of dissociating LPS micelles and disrupting LPS aggregates into smaller assemblies, which may play a vital role in its antimicrobial activity. Using LPS-stimulated mouse macrophage RAW264.7 cells, we found that cecropin DH exerted higher potential anti-inflammatory activity than cecropin B, as demonstrated by the inhibition of pro-inflammatory cytokines nitric oxide production and secretion of tumor necrosis factor-alpha. In conclusion, cecropin DH has potential as a therapeutic agent for both antibacterial and anti-inflammatory applications. |
资助项目 | National Natural Science Foundation of China[21502196] ; National Natural Science Foundation of China[21473210] ; National Natural Science Foundation of China[21372222] ; National Natural Science Foundation of China[U1532269] |
WOS关键词 | HELICAL ANTIMICROBIAL PEPTIDES ; GRAM-NEGATIVE BACTERIA ; HOST-DEFENSE PEPTIDES ; LIPOPOLYSACCHARIDE-BINDING ; ESCHERICHIA-COLI ; CELL SELECTIVITY ; INNATE IMMUNITY ; ALPHA ; MECHANISM ; NMR |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | PEERJ INC |
WOS记录号 | WOS:000439944000011 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/37784] |
专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
通讯作者 | Sun, Hongbin; Wang, Junfeng |
作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China 3.Xinxiang Med Univ, Affiliated Hosp 1, Xinxiang, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing, Peoples R China 5.Hefei Univ Technol, Sch Chem & Chem Engn, Hefei, Anhui, Peoples R China 6.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou, Henan, Peoples R China 7.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Jiarong,Ma, Kun,Ruan, Maosen,et al. A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties[J]. PEERJ,2018,6:21. |
APA | Wang, Jiarong.,Ma, Kun.,Ruan, Maosen.,Wang, Yujuan.,Li, Yan.,...&Wang, Junfeng.(2018).A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties.PEERJ,6,21. |
MLA | Wang, Jiarong,et al."A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties".PEERJ 6(2018):21. |
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