Effects of Blidingia sp. Extract on Intestinal Inflammation and Microbiota Composition in LPS-Challenged Mice

doi:10.3389/fphys.2019.00763

CORC > 自然资源部第一海洋研究所 > 自然资源部第一海洋研究所 > 业务部门 > 海洋生态研究中心

	Effects of Blidingia sp. Extract on Intestinal Inflammation and Microbiota Composition in LPS-Challenged Mice
	Song, Wei 1,2; Li, Yan 1,2; Zhang, Xuelei 1,2; Wang, Zongling 1,2
刊名	FRONTIERS IN PHYSIOLOGY
	2019-06-25
卷号	10
关键词	apoptosis Blidingia sp. inflammation microbiota morphology
ISSN号	1664-042X
DOI	10.3389/fphys.2019.00763
英文摘要	Blidingia sp. is a green alga that has spread rapidly in Subei Shoal, China. To explore the potential beneficial effects of Blidingia sp., we investigated the anti-inflammatory activity of its water-methanol extract of Blidingia sp. in a mouse model of lipopolysaccharide (LPS)-induced intestinal inflammation. The results revealed that the administration of Blidingia extract significantly alleviated the LPS-induced increase of the inflammatory cytokine content in the serum, as well as latter's gene expression in the ileum. Moreover, the extract inhibited the phosphorylation of NF-kappa B and l kappa B alpha in LPS-challenged mice. Apart from these changes, the extract also averted intestinal morphology damage(s) and cell apoptosis in mice. Interestingly, the extract also had beneficial effects on the diversity and composition of caecal microbiota in LPS-challenged mice. In conclusion, the results suggested that Blidingia extract had beneficial effects on the recovery of intestinal function by reducing the inflammatory response, improving the maintenance of intestinal morphology, and decreasing cell apoptosis in LPS-induced intestinal inflammation. In addition, the beneficial effects of the extract on caecal microbiota composition may play a role in its anti-inflammatory activity. These results suggested that Blidingia extract could be potentially used in preventing intestinal inflammation.
URL标识	查看原文
资助项目	Open Fund of CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences[KLMEES201803]
WOS研究方向	Physiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000473206900002
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/27663]
专题	业务部门_海洋生态研究中心
通讯作者	Wang, Zongling
作者单位	1.Minist Nat Resources Peoples Republ China, Key Lab Sci & Engn Marine Ecol & Environm, Inst Oceanog 1, Qingdao, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Song, Wei,Li, Yan,Zhang, Xuelei,et al. Effects of Blidingia sp. Extract on Intestinal Inflammation and Microbiota Composition in LPS-Challenged Mice[J]. FRONTIERS IN PHYSIOLOGY,2019,10.
APA	Song, Wei,Li, Yan,Zhang, Xuelei,&Wang, Zongling.(2019).Effects of Blidingia sp. Extract on Intestinal Inflammation and Microbiota Composition in LPS-Challenged Mice.FRONTIERS IN PHYSIOLOGY,10.
MLA	Song, Wei,et al."Effects of Blidingia sp. Extract on Intestinal Inflammation and Microbiota Composition in LPS-Challenged Mice".FRONTIERS IN PHYSIOLOGY 10(2019).