Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2

doi:10.1007/s00343-016-5097-y

	Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2
	Li Peihai 7; Fan Yaqin 7; Chen Hao 7; Chao Yaxi 7; Du Ning 7; Chen Junhui 7
刊名	Chinese Journal of Oceanology and Limnology
	2016
卷号	34 期号:5 页码:1072-1075
关键词	phenylquinolinones anti-tumor Aspergillus versicolor
ISSN号	0254-4059
DOI	10.1007/s00343-016-5097-y
英文摘要	Two phenylquinolinones, including one new compound (1) and a previously isolated compound (2), were isolated from the ethyl acetate extracts of the fungus Aspergillus versicolor Y31-2, which was obtained from seawater samples collected from the Indian Ocean. The structures of these compounds were established by spectroscopic analyses. 4-(3-Hydroxyphenyl)-3-methoxyquinolin-2(1H)-one (1) exhibited moderate cytotoxicity against MCF-7 (human breast carcinoma cell line) and SMMC-7721 (human liver cancer cell line) cells with IC_(50) values of 16.6 and 18.2 mumol/L, respectively. To the best of our knowledge, this study represents the first reported account of the isolation of compounds 1 and 2 as the secondary metabolites of the seawater derived fungus Aspergillus versicolor from the Indian Ocean.
资助项目	Supported by the National Basic Research Program of China (973 Program) ; the National High Technology Research and Development Program of China (863 Program) ; the China Ocean Mineral Resources Research and Development Association ; the Public Welfare Project of SOA ; the Basic Scientific Fund for National Public Research Institutes of China
WOS关键词	METABOLITES ; INHIBITOR
WOS研究方向	Science & Technology - Other Topics
语种	英语
CSCD记录号	CSCD:5773052
WOS记录号	WOS:000379737000019
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/29781]
专题	自然资源部第一海洋研究所
作者单位	1.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 2.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 3.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 4.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 5.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 6.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 7.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 8.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 9.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China 10.First Institute of Oceanography, State Oceanic Administration (SOA), Key Lab of Marine Bioactive Substances,State Oceanic Administration (SOA), Qingdao, Shandong 266000, China
推荐引用方式 GB/T 7714	Li Peihai,Fan Yaqin,Chen Hao,et al. Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2[J]. Chinese Journal of Oceanology and Limnology,2016,34(5):1072-1075.
APA	Li Peihai,Fan Yaqin,Chen Hao,Chao Yaxi,Du Ning,&Chen Junhui.(2016).Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2.Chinese Journal of Oceanology and Limnology,34(5),1072-1075.
MLA	Li Peihai,et al."Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2".Chinese Journal of Oceanology and Limnology 34.5(2016):1072-1075.