Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds

doi:10.1039/c7tb00479f

	Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds
	Xia, Guixue 1; Liu, Ya 1; Tian, Meiping 1; Gao, Ping 2; Bao, Zixian 1; Bai, Xiaoyu 1; Yu, Xiaoping 1; Lang, Xuqian 1; Hu, Shihao 1; Chen, Xiguang 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2017-05-07
卷号	5 期号:17 页码:3172-3185
ISSN号	2050-750X
DOI	10.1039/c7tb00479f
英文摘要	Cutaneous chronic wounds are characterized by impaired wound healing which may lead to infection and even amputation. To surmount this problem, we developed a chitin whisker (CW)/carboxymethyl chitosan nanoparticles (CMCS NPs)/thermosensitive hydroxybutyl chitosan (HBC) composite hydrogel (CW/NPs/HBC-HG) as a wound dressing for treating chronic wounds. Upon introduction of CWs, the composite hydrogel exhibited a significant decrease in gelation temperature and enhanced mechanical properties. The storage modulus (G') of the CW/NPs/HBC-HG was 3.6 times that of the NPs/HBC-HG at 37 degrees C and the ex vivo rat skin test also showed that the mechanical properties were significantly improved. Linezolid, a wide-spectrum antibiotic, was dissolved directly in the water phase of the composite hydrogel, and the antibacterial activity of the composite hydrogel against Escherichia coli and Staphylococcus aureus was up to 99% until 7 days. When recombinant human epidermal growth factor (rhEGF) was encapsulated into the NPs, the CW/NPs/HBC-HG offered prolonged cell proliferation activity up to 5 days. More importantly, the in vivo chronic wound healing model evaluation in diabetic rats revealed that the CW/NPs/HBC-HG dressing promoted wound healing and accelerated reepithelialization, collagen deposition and angiogenesis. These findings demonstrated that CW/NPs/HBC-HG is a promising dressing for chronic wounds.
资助项目	Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS[NSKF201604]
WOS关键词	EPIDERMAL-GROWTH-FACTOR ; IN-VIVO EVALUATION ; DRUG DELIVERY-SYSTEM ; ELECTROSPUN NANOFIBERS ; CONTROLLED-RELEASE ; POLYURETHANE FOAM ; CHITOSAN ; NANOCOMPOSITE ; VITRO ; NANOPARTICLES
WOS研究方向	Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000400501900011
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/27414]
专题	自然资源部第一海洋研究所
通讯作者	Liu, Ya; Chen, Xiguang
作者单位	1.Ocean Univ China, Coll Marine Life Sci, 5 Yushan Rd, Qingdao 266003, Shandong, Peoples R China 2.First Inst Oceanog SOA, Qingdao 266061, Peoples R China
推荐引用方式 GB/T 7714	Xia, Guixue,Liu, Ya,Tian, Meiping,et al. Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(17):3172-3185.
APA	Xia, Guixue.,Liu, Ya.,Tian, Meiping.,Gao, Ping.,Bao, Zixian.,...&Chen, Xiguang.(2017).Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds.JOURNAL OF MATERIALS CHEMISTRY B,5(17),3172-3185.
MLA	Xia, Guixue,et al."Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds".JOURNAL OF MATERIALS CHEMISTRY B 5.17(2017):3172-3185.