New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp.

doi:10.1016/j.phytol.2015.04.001

	New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp.
	Huang, Huarong 1,2; Lan, Xiong 1; Wang, Yanlei 1; Tian, Li 3,4; Fang, Yanxiong 1; Zhang, Lei 1; Zhang, Kun 1; Zheng, Xi 1,2
刊名	PHYTOCHEMISTRY LETTERS
	2015-06
卷号	12 页码:190-195
关键词	Nonactic acid Homononactic acid Streptomyces griseus Salicornia sp.
ISSN号	1874-3900
DOI	10.1016/j.phytol.2015.04.001
英文摘要	Three new compounds, butyl homononactate (5), butyl nonactate (6), 8-actyl homononactic acid (7), along with four known compounds homononactic acids (1), nonactic acid (2), homononactyl nonactate (3), homononactyl homononactate (4) were isolated from the marine Streptomyces griseus RSH0407, derived from the plant Salicornia sp., Chenopodiaceae. Their structures were elucidated by extensive spectroscopic techniques and by comparison with data reported in the literature. The absolute configuration of 3 was first reported by using X-ray copper radiation. Compound 5 exhibited cytotoxic activities against the HCT-8, A2780, BGC-823, BEL-7402, and A549 cell lines in vitro, with IC50 values of 2.87 +/- 0.20, 4.90 +/- 0.30, 2.19 +/- 0.32, 5.07 +/- 0.23 and 1.78 +/- 0.18 mu M, respectively, and compounds 4-7 showed weak antibacterial activities against four bacterials respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
资助项目	National Key Technologies RD Program[2011BAE06B04]
WOS关键词	MACROTETROLIDE ANTIBIOTICS ; HERBACEA
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000356336400037
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/25781]
专题	自然资源部第一海洋研究所
通讯作者	Huang, Huarong
作者单位	1.Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China 2.Rutgers State Univ, Dept Biol Chem, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA 3.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Peoples R China 4.Qingdao Univ Sci & Technol, Qingdao 266042, Peoples R China
推荐引用方式 GB/T 7714	Huang, Huarong,Lan, Xiong,Wang, Yanlei,et al. New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp.[J]. PHYTOCHEMISTRY LETTERS,2015,12:190-195.
APA	Huang, Huarong.,Lan, Xiong.,Wang, Yanlei.,Tian, Li.,Fang, Yanxiong.,...&Zheng, Xi.(2015).New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp..PHYTOCHEMISTRY LETTERS,12,190-195.
MLA	Huang, Huarong,et al."New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp.".PHYTOCHEMISTRY LETTERS 12(2015):190-195.