Mechanical properties, in vitro degradation behavior, hemocompatibility   and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants

doi:10.1039/c6ra14300h

CORC > 北京大学 > 工学院

	Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants
	Shen, Chao ; Liu, Xiwei ; Fan, Bo ; Lan, Pingheng ; Zhou, Feiyu ; Li, Xiaokang ; Wang, Hailiang ; Xiao, Xin ; Li, Li ; Zhao, Shen ; Guo, Zheng ; Pu, Zhongjie ; Zheng, Yufeng
刊名	RSC ADVANCES
	2016
关键词	ZN-BASED ALLOYS MAGNESIUM ALLOYS CORROSION BEHAVIOR ZN-3MG ALLOY ELEMENTS MG MICROSTRUCTURE ZINC SR METALS CA
DOI	10.1039/c6ra14300h
英文摘要	Zn, which is a promising alternative candidate as a biodegradable implant material, possesses excellent biocompatibility and biodegradability. However, the insufficiency of its strength and hardness has largely limited its application. Nevertheless, adding alloying elements and mechanical forming by extrusion have generally enhanced its mechanical properties. In the present work, Zn-1.2Mg alloy has been designed and treated by extrusion. Experimental results demonstrated that the studied alloys were composed of a matrix of Zn and a precipitated phase of Mg2Zn11, and the grain size became smaller and more homogeneous after extrusion. The as-extruded alloy exhibited much higher yield strength (YS 219.61 MPa), ultimate tensile strength (UTS 362.64 MPa), elongation (21.31%) and hardness (96.01 HV). The corrosion rates of the as-extruded alloy were higher compared with those of the as-cast alloy and reached values of 0.19 mm per year in electrochemical tests and 0.11 mm per year after exposure in Hank's solution for 30 days, respectively. Moreover, the as-extruded alloy displayed excellent hemocompatibility (hemolysis rate of 1.85%, superior thromboresistance and no signs of thrombogenicity). The viability of human osteosarcoma HOS cells and MG63 cells cultured in diluted extracts of the alloy exceeded 70%, which demonstrated no potential cytotoxicity and tolerance in cellular applications.; Lepu Medical Technology (Beijing) Co., Ltd; National Natural Science Foundation of China [51271199, 51501223]; National High-tech R&D Program (863 Program) [2015AA033702]; SCI(E); EI; ARTICLE; guozheng@fmmu.edu.cn; Zhongjiepu2009@163.com; yfzheng@pku.edu.cn; 89; 86410-86419; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/494898]
专题	工学院
推荐引用方式 GB/T 7714	Shen, Chao,Liu, Xiwei,Fan, Bo,et al. Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants[J]. RSC ADVANCES,2016.
APA	Shen, Chao.,Liu, Xiwei.,Fan, Bo.,Lan, Pingheng.,Zhou, Feiyu.,...&Zheng, Yufeng.(2016).Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants.RSC ADVANCES.
MLA	Shen, Chao,et al."Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants".RSC ADVANCES (2016).