Evolution of the degradation mechanism of pure zinc stent in the   one-year study of rabbit abdominal aorta model

doi:10.1016/j.biomaterials.2017.08.022

CORC > 北京大学 > 工学院

	Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model
	Yang, Hongtao ; Wang, Cong ; Liu, Chaoqiang ; Chen, Houwen ; Wu, Yifan ; Han, Jintao ; Jia, Zichang ; Lin, Wenjiao ; Zhang, Deyuan ; Li, Wenting ; Yuan, Wei ; Guo, Hui ; Li, Huafang ; Yang, Guangxin ; Kong, Deling ; Zhu, Donghui ; Takashima, Kazuki ; Ruan, Liqun ; Nie, Jianfeng ; Li, Xuan ; Zheng, Yufeng
刊名	BIOMATERIALS
	2017
关键词	Pure zinc stent Rabbit abdominal aorta Degradation behavior Degradation mechanism Biocompatibility PORCINE CORONARY-ARTERIES MAGNESIUM ALLOY STENTS OPTICAL COHERENCE TOMOGRAPHY ABSORBABLE METAL SCAFFOLD IN-VITRO INTRAVASCULAR ULTRASOUND BIOMEDICAL APPLICATIONS CARDIOVASCULAR STENTS BIOABSORBABLE STENTS BIODEGRADABLE METALS
DOI	10.1016/j.biomaterials.2017.08.022
英文摘要	In the present study, pure zinc stents were implanted into the abdominal aorta of rabbits for 12 months. Multiscale analysis including micro-CT, scanning electron microscopy (SEM), scanning transmission electron microscopy (STEM) and histological stainings was performed to reveal the fundamental degradation mechanism of the pure zinc stent and its biocompatibility. The pure zinc stent was able to maintain mechanical integrity for 6 months and degraded 41.75 +/- 29.72% of stent volume after 12 months implantation. No severe inflammation, platelet aggregation, thrombosis formation or obvious intimal hyperplasia was observed at all time points after implantation. The degradation of the zinc stent played a beneficial role in the artery remodeling and healing process. The evolution of the degradation mechanism of pure zinc stents with time was revealed as follows: Before endothelialization, dynamic blood flow dominated the degradation of pure zinc stent, creating a uniform corrosion mode; After endothelialization, the degradation of pure zinc stent depended on the diffusion of water molecules, hydrophilic solutes and ions which led to localized corrosion. Zinc phosphate generated in blood flow transformed into zinc oxide and small amounts of calcium phosphate during the conversion of degradation microenvironment. The favorable physiological degradation behavior makes zinc a promising candidate for future stent applications. (C) 2017 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [51431002]; NSFC/RGC Joint Research Scheme [51361165101, 5161101031]; NSFC-RFBR Cooperation Project [51611130054]; SCI(E); ARTICLE; 92-105; 145
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/484565]
专题	工学院
推荐引用方式 GB/T 7714	Yang, Hongtao,Wang, Cong,Liu, Chaoqiang,et al. Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model[J]. BIOMATERIALS,2017.
APA	Yang, Hongtao.,Wang, Cong.,Liu, Chaoqiang.,Chen, Houwen.,Wu, Yifan.,...&Zheng, Yufeng.(2017).Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model.BIOMATERIALS.
MLA	Yang, Hongtao,et al."Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model".BIOMATERIALS (2017).