Electrically Evoked Responses in the Rabbit Cortex Induced by Current   Steering With Penetrating Optic Nerve Electrodes

doi:10.1167/iovs.15-17543

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	Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes
	Yan, Yan ; Lu, Yiliang ; Li, Menghui ; Ma, Zengguang ; Cao, Pengjia ; Chen, Yao ; Sun, Xiaodong ; Chai, Xinyu ; Ren, Qiushi ; Li, Liming
刊名	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
	2016
关键词	visual prosthesis optic nerve electrical stimulation current steering electrophysiology and simulation SUPRACHOROIDAL-TRANSRETINAL STIMULATION RETINAL PROSTHESIS SUBJECTS CAT VISUAL-CORTEX CHANNEL INTERACTIONS MICROELECTRODE ARRAY RETINITIS-PIGMENTOSA COCHLEAR IMPLANTS OCCIPITAL CORTEX GANGLION-CELLS POTENTIALS
DOI	10.1167/iovs.15-17543
英文摘要	PURPOSE. Current steering is a neural stimulation strategy that uses simultaneous stimulation of adjacent electrodes to produce additional intermediate stimulation sites and thus improves spatial resolution. We investigated the feasibility of current steering using electrophysiological and computational methods after implanting paired penetrating electrodes into the rabbit's optic nerve (ON). METHODS. Penetrating electrodes at different interelectrode distances were implanted into the ON and electrically evoked cortical potentials (EEPs) in V1 recorded with a 6 x 8 array. The current thresholds, EEP amplitudes, and spatial distributions were analyzed during current steering. Computational simulation studies were performed based on finite element models to calculate the area and spatial distribution of recruited ON fibers using a current steering stimulation strategy. RESULTS. Threshold reduction and EEP amplitude enhancement were found with simultaneous stimulation of closely spaced electrode pairs. Spatially shifted cortical responses were achieved using current steering, whereas the amplitudes and spatial spreads of the responses were similar to that elicited by a single electrode. Computational simulations suggested that the centroid of the ON recruitment area could be modulated by current steering while the total recruitment area did not show any appreciable variability at a fixed current intensity. CONCLUSIONS. Current steering is a useful strategy to enhance the spatial resolution of an ON prosthesis without increasing the number of physical electrodes. This study provides useful information for optimizing the design of stimulation strategies with a penetrating ON prosthesis.; National Basic Research Program of China (973 Program) [2011CB707502]; National Natural Science Foundation of China [61671300, 61171174, 60971102, 91120304, 61472247]; SCI(E); ARTICLE; lilm@sjtu.edu.cn; 14; 6327-6338; 57
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/458502]
专题	工学院
推荐引用方式 GB/T 7714	Yan, Yan,Lu, Yiliang,Li, Menghui,et al. Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2016.
APA	Yan, Yan.,Lu, Yiliang.,Li, Menghui.,Ma, Zengguang.,Cao, Pengjia.,...&Li, Liming.(2016).Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.
MLA	Yan, Yan,et al."Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016).