Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect

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	Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect
	Lin Li ; Li Xiaoda ; Yang Yongbo ; Jing Lijia ; Yue Xiuli ; Chen Xuzhu ; Dai Zhifei
刊名	Current drug delivery
	2016
英文摘要	The chitosan functionalized CuS nanoparticles around 15 nm were successfully engineered by employing hydrothermal method. The modification of CuS nanoparticles with chitosan conduced to higher physiological stability and biocompatibility. The utilization of CuS@CS NPs in combination with external near infrared (NIR) laser irradiation could enhance gene transfection efficiency due to photothermal effect. The gene transfection efficiency of CuS@CS NPs found to increase from 5.05 ± 0.54% (0 min) to 23.47 ± 1.27% (10 min), significantly higher than the free polyethylenimine (18.15 ± 1.03%). Therefore CuS@CS NPs showed great capability to control gene delivery by an external NIR laser irradiation and enhance the gene transfection efficiency and specificity because of convenient preparation, stabilized optical properties, excellent photothermal effect and good biocompatibility. It encourages further exploration of the CuS@CS NPs as a photocontrollablenanovector for combined photothermal and gene therapy, as well as image guided therapy.; PubMed
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435462]
专题	工学院
推荐引用方式 GB/T 7714	Lin Li,Li Xiaoda,Yang Yongbo,et al. Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect[J]. Current drug delivery,2016.
APA	Lin Li.,Li Xiaoda.,Yang Yongbo.,Jing Lijia.,Yue Xiuli.,...&Dai Zhifei.(2016).Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect.Current drug delivery.
MLA	Lin Li,et al."Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect".Current drug delivery (2016).