Noninvasive Measurement of Renal Oxygen Extraction Fraction Under the   Influence of Respiratory Challenge

doi:10.1002/jmri.25163

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	Noninvasive Measurement of Renal Oxygen Extraction Fraction Under the Influence of Respiratory Challenge
	Wang, Chengyan ; Zhang, Rui ; Wang, Rui ; Jiang, Li ; Zhang, Xiaodong ; Wang, He ; Zhao, Kai ; Jin, Lixin ; Zhang, Jue ; Wang, Xiaoying ; Fang, Jing
刊名	JOURNAL OF MAGNETIC RESONANCE IMAGING
	2016
关键词	carbogen breathing,renal oxygen extraction,respiratory challenge,susceptibility LEVEL-DEPENDENT MR BOLD-MRI INTRARENAL OXYGENATION DIABETIC-NEPHROPATHY RENOVASCULAR DISEASE INITIAL-EXPERIENCE QUANTITATIVE BOLD SIGNAL BEHAVIOR BLOOD-VOLUME HYPOXIA
DOI	10.1002/jmri.25163
英文摘要	Purpose: To demonstrate the feasibility of using a susceptibility-based magnetic resonance imaging (MRI) technique for measuring renal oxygen extraction fraction (OEF) changes under the influence of carbogen (97% O-2, 3% CO2) breathing. Materials and Methods: Eight New Zealand White rabbits were included in this study with local animal care committee approval. For OEF measurement, an asymmetric spin echo (ASE) sequence was used to acquire source images and a susceptibility model was utilized for OEF estimation at 3.0T. Within-session and between-day tests were conducted to evaluate the reproducibility of this OEF measurement. OEF changes were measured under respiratory challenge with alternated air and carbogen (97% O-2, 3% CO2) breathing. For comparison, blood samples were collected for the measurement of pO(2). Results: The within-session coefficients of variation (CVs) of renal OEF measurements were 6.62% in cortex and 5.92% in medulla, while between-day CVs were 7.52% in cortex and 8.03% in medulla. Under carbogen breathing, renal OEFs decreased significantly from 0.32 +/- 0.03 to 0.28 +/- 0.02 (P < 0.01) in cortex, and from 0.34 +/- 0.04 to 0.31 +/- 0.03 (P < 0.01) in medulla. No statistical difference of relative OEF change was seen between cortex and medulla (P=0.93). In addition, negative correlation between renal OEF and blood pO(2) was found (r=0.68 (P < 0.05) in cortex, and r=0.64 (P < 0.05) in medulla). Conclusion: This study demonstrates the feasibility of using a susceptibility-based OEF measurement method for the evaluation of renal oxygenation changes induced by carbogen breathing.; SCI(E); PubMed; ARTICLE; zhangjue@pku.edu.cn; cjr.wangxiaoying@vip.163.com; 1; 230-237; 44
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435271]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Chengyan,Zhang, Rui,Wang, Rui,et al. Noninvasive Measurement of Renal Oxygen Extraction Fraction Under the Influence of Respiratory Challenge[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2016.
APA	Wang, Chengyan.,Zhang, Rui.,Wang, Rui.,Jiang, Li.,Zhang, Xiaodong.,...&Fang, Jing.(2016).Noninvasive Measurement of Renal Oxygen Extraction Fraction Under the Influence of Respiratory Challenge.JOURNAL OF MAGNETIC RESONANCE IMAGING.
MLA	Wang, Chengyan,et al."Noninvasive Measurement of Renal Oxygen Extraction Fraction Under the Influence of Respiratory Challenge".JOURNAL OF MAGNETIC RESONANCE IMAGING (2016).