Uniform and accelerated degradation of pure iron patterned by Pt disc   arrays

doi:10.1038/srep23627

CORC > 北京大学 > 工学院

	Uniform and accelerated degradation of pure iron patterned by Pt disc arrays
	Huang, Tao ; Zheng, Yufeng
刊名	SCIENTIFIC REPORTS
	2016
关键词	FE-MN ALLOYS IN-VITRO DEGRADATION BIODEGRADABLE STENTS CORONARY STENTS CELL VIABILITY BIOCOMPATIBILITY SURFACES MICROSTRUCTURE COMPOSITES CORROSION
DOI	10.1038/srep23627
英文摘要	Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Phi 20 mu m x S5 mu m and F4 mu m x S4 mu m, have been coated on the surface of pure iron. Corrosion tests showed the platinum discs formed plenty of galvanic cells with the iron matrix which significantly accelerated the degradation of pure iron. Simultaneously, due to the designability of the shape, size as well as distribution of Pt discs, the degradation rate as well as degradation uniformity of pure iron can be effectively controlled by coating with platinum discs. The cytotoxicity test results unveiled that Pt discs patterned pure iron exhibited almost no toxicity to human umbilical vein endothelial cells, but a significant inhibition on proliferation of vascular smooth muscle cells. In addition, the hemolysis rate of Pt discs patterned pure iron was lower than 1%. Moreover, Pt discs also effectively reduced the number of adhered platelets. All these results indicated that Pt discs patterning is an effective way to accelerate degradation and improve biocompatibility of pure iron.; National Basic Research Program of China (973 Program) [2012CB619102]; National Science Fund for Distinguished Young Scholars [51225101]; National Natural Science Foundation of China [51431002, 31170909]; Beijing Municipal Science and Technology Project [Z141100002814008]; SCI(E); PubMed; ARTICLE; yfzheng@pku.edu.cn; 23627; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434297]
专题	工学院
推荐引用方式 GB/T 7714	Huang, Tao,Zheng, Yufeng. Uniform and accelerated degradation of pure iron patterned by Pt disc arrays[J]. SCIENTIFIC REPORTS,2016.
APA	Huang, Tao,&Zheng, Yufeng.(2016).Uniform and accelerated degradation of pure iron patterned by Pt disc arrays.SCIENTIFIC REPORTS.
MLA	Huang, Tao,et al."Uniform and accelerated degradation of pure iron patterned by Pt disc arrays".SCIENTIFIC REPORTS (2016).